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miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3

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Tumor Biology

Abstract

MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC. Decreased expression of miR-141 was observed in both HCC tissues and cell lines. Ectopic overexpression of miR-141 reduced proliferation, migration, and invasion of HCC cells. E2F transcription factor 3 (E2F3) was confirmed to be a target of miR-141 in HCC cells. Moreover, restoration of E2F3 significantly reversed the tumor suppressive effects of miR-141. Our results suggest a critical role of miR-141 in suppressing metastasis of HCC cells by targeting E2F3.

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Authors and Affiliations

  1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jun Xue, Jing Huang, Gang Peng & Yu-Hui Yang

  2. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yan-Feng Niu

  3. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Li-xia Wang

  4. Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yun-Qiao Li

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  1. Jun Xue
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  2. Yan-Feng Niu
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  3. Jing Huang
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  4. Gang Peng
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  5. Li-xia Wang
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  7. Yun-Qiao Li
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Correspondence to Yun-Qiao Li.

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Xue, J., Niu, YF., Huang, J. et al. miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3. Tumor Biol. 35, 12103–12107 (2014). https://doi.org/10.1007/s13277-014-2513-9

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  • DOI: https://doi.org/10.1007/s13277-014-2513-9

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