Comment on Zhuang YF et al.: Impact of vascular endothelial growth factor expression on overall survival in patients with osteosarcoma: a meta-analysis
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To the Editor:
In this meta-analysis, Zhuang et al.  performed a systematic review to assess the impact of vascular endothelial growth factor (VEGF) expression on overall survival in patients with osteosarcoma by calculating the pooled hazard ratio (HR) with corresponding 95 % confidence interval (95 % CI). They reached an important conclusion that VEGF expression has an important impact on overall survival in patients with osteosarcoma and high VEGF expression is associated with poorer overall survival. It is a valuable study. Nevertheless, there are some comments we would like to raise related to this article.
Firstly, we think there are some deficiencies in the literature search. Two electronic databases (PubMed and Web of Science databases) were systematically searched by the investigators (Zhuang YF et al.). The small number of required papers would be an important limitation of this meta-analysis. We hope that more electronic databases can be systematically searched....
KeywordsVascular Endothelial Growth Factor Osteosarcoma Publication Bias Vascular Endothelial Growth Factor Expression Manual Search
Conflicts of interest
- 10.Chen GL, Lin HB, Wu XW, Li RY, Chen XH. The correlation between the level of serum VEGF and BFGF with metastasis and prognosis of osteosarcoma. Chin J Cell Mol Immunol. 2011;27:1343–5.Google Scholar