Tumor Biology

, Volume 35, Issue 9, pp 8533–8534 | Cite as

Comment on Zhuang YF et al.: Impact of vascular endothelial growth factor expression on overall survival in patients with osteosarcoma: a meta-analysis

  • Jinlong Ma
  • Ling Fang
  • Feng Zhang
Research Commentary

To the Editor:

In this meta-analysis, Zhuang et al. [1] performed a systematic review to assess the impact of vascular endothelial growth factor (VEGF) expression on overall survival in patients with osteosarcoma by calculating the pooled hazard ratio (HR) with corresponding 95 % confidence interval (95 % CI). They reached an important conclusion that VEGF expression has an important impact on overall survival in patients with osteosarcoma and high VEGF expression is associated with poorer overall survival. It is a valuable study. Nevertheless, there are some comments we would like to raise related to this article.

Firstly, we think there are some deficiencies in the literature search. Two electronic databases (PubMed and Web of Science databases) were systematically searched by the investigators (Zhuang YF et al.). The small number of required papers would be an important limitation of this meta-analysis. We hope that more electronic databases can be systematically searched....


Vascular Endothelial Growth Factor Osteosarcoma Publication Bias Vascular Endothelial Growth Factor Expression Manual Search 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.The Department of Health MonitoringXi’an Center for Disease Control and PreventionXi’anPeople’s Republic of China
  2. 2.Department of UltrasonicXi’an Children’s HospitalXi’anPeople’s Republic of China

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