Tumor Biology

, Volume 36, Issue 4, pp 2257–2261 | Cite as

Prognostic role of serum carbohydrate antigen 19-9 levels in patients with resectable hepatocellular carcinoma

  • Jinyan Zhang
  • Tao Huang
  • Fan Zhang
  • Junming Xu
  • Guoqing Chen
  • Xiaoliang Wang
  • Li Huang
  • Zhihai Peng
Research Article


Serum levels of carbohydrate antigen 19-9 (CA 19-9) were shown to be associated with poorer prognosis in several cancers, but the prognostic role of CA 19-9 levels in patients with hepatocellular carcinoma was unclear. A retrospective cohort of 97 patients with resectable hepatocellular carcinoma was performed to assess the prognostic role of CA 19-9 levels on overall survival in hepatocellular carcinoma. Both Kaplan-Meier product-limit method and multivariate analysis were performed to determine the prognostic role of CA 19-9 levels. The results indicated that among those 97 patients, 24 (24.7 %) had elevated preoperative CA 19-9 levels (≥37 U/mL). Elevated serum CA 19-9 levels did not correlate with patient age, gender, tumor size, tumor stage, diabetes, and hepatitis B virus (HBV) infection. Kaplan-Meier product-limit method showed that patients with elevated CA 19-9 levels had poorer survival than those with normal CA 19-9 levels (log-rank test P < 0.001). Multivariate analysis showed that elevated CA 19-9 level was a significantly independent predictor of poorer overall survival (hazard ratio [HR] = 2.56; 95 % confidence interval [95 % CI] 1.41–4.64, P = 0.002). In addition, tumor stages and multiple tumors were also independent predictors of poorer overall survival in hepatocellular carcinoma (P < 0.01). In conclusion, serum CA 19-9 levels have an independent prognostic role in patients with resectable hepatocellular carcinoma. Elevated CA 19-9 level is significantly associated with poorer overall survival in hepatocellular carcinoma.


Hepatocellular carcinoma Carbohydrate antigen 19-9 Overall survival 



This work was supported by National Natural Science Foundation of China (81200328) and Shanghai Natural Science Foundation (12ZR1424100).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Jinyan Zhang
    • 1
  • Tao Huang
    • 2
  • Fan Zhang
    • 1
  • Junming Xu
    • 1
  • Guoqing Chen
    • 1
  • Xiaoliang Wang
    • 1
  • Li Huang
    • 1
  • Zhihai Peng
    • 1
  1. 1.Department of General Surgery, Shanghai First People’s HospitalShanghai Jiaotong UniversityShanghaiChina
  2. 2.Clinical LaboratoryBaoshan Branch of Shanghai First People’s HospitalShanghaiChina

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