Tumor Biology

, Volume 35, Issue 11, pp 11121–11127 | Cite as

Calponin-h2: a potential serum marker for the early detection of human breast cancer?

  • Manuel Debald
  • Jian-Ping Jin
  • Andrea Linke
  • Klaus-Jürgen Walgenbach
  • Peter Rauch
  • Angela Zellmer
  • Rolf Fimmers
  • Walther Kuhn
  • Gunther Hartmann
  • Gisela Walgenbach-Brünagel
Research Article


Early diagnosis is the key for the successful treatment of breast cancer. A serum marker for the early detection of breast cancer could significantly reduce breast cancer morbidity and mortality by bringing the time of diagnosis at an earlier and therefore still curable stage. So far, no biomarker for the early detection is available for the clinical routine. The aim of the present study was to evaluate the use of calponin-h2 as a blood-based biomarker for the early diagnosis of this disease. Using two monoclonal antibodies against calponin-h2, we developed a sandwich ELISA to analyze the serum levels of calponin-h2. In order to evaluate the diagnostic potential of this biomarker, patients with breast cancer (n = 76), benign diseases of the breast (n = 51) and healthy females (n = 24) were analyzed. Serum levels above 10 ng/ml were only observed in patients with breast cancer (n = 8; 10.5 %). Further large-scale studies and preanalytic evaluations are necessary to clarify the definite role of calponin-h2 as a biomarker in breast cancer management.


Breast cancer Biomarker Calponin-h2 Screening Diagnosis 



Manuel Debald is funded by BONFOR, University of Bonn.

Conflict of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Manuel Debald
    • 1
  • Jian-Ping Jin
    • 2
  • Andrea Linke
    • 3
  • Klaus-Jürgen Walgenbach
    • 4
  • Peter Rauch
    • 5
  • Angela Zellmer
    • 5
  • Rolf Fimmers
    • 6
  • Walther Kuhn
    • 1
  • Gunther Hartmann
    • 3
  • Gisela Walgenbach-Brünagel
    • 3
  1. 1.Department of Obstetrics and Gynecology, Centre for Integrated OncologyUniversity of BonnBonnGermany
  2. 2.Department of PhysiologyWayne State University School of MedicineDetroitUSA
  3. 3.Institute for Clinical Chemistry and Clinical Pharmacology, Centre for Integrated OncologyUniversity of BonnBonnGermany
  4. 4.Department of Plastic and Aesthetic SurgeryUniversity of BonnBonnGermany
  5. 5.CANDOR Bioscience GmbHWangenGermany
  6. 6.Institute for Medical Biometry, Informatics and Epidemiology (IMBIE)University of BonnBonnGermany

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