Tumor Biology

, Volume 35, Issue 11, pp 11021–11025 | Cite as

Downregulation of DYRK2 can be a predictor of recurrence in early stage breast cancer

  • Yasuko Enomoto
  • Shin-ichi Yamashita
  • Yasuteru Yoshinaga
  • Yasuyoshi Fukami
  • So Miyahara
  • Kazuki Nabeshima
  • Akinori Iwasaki
Research Article


This study investigated the potential of DYRK2, a dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase gene, to predict disease-free survival for patients with early stage breast cancer. Two hundred and seventy-four patients with breast cancer underwent surgery from January 2000 to December 2009. All patients were in stage I or II. Immunohistochemical (IHC) analysis was used to determine the expression of DYRK2, which was examined for its association with clinicopathological factors or prognosis. A total of 85 of 274 cases (31 %) were DYRK2 positive. No correlation was found between DYRK2 expression by IHC and clinicopathological factors such as tumor size, histological grade, hormone receptor status, and HER2 status; however, lymph node involvement was closely associated with DYRK2 expression. Ten-year disease-free survival in the DYRK2-positive group without node metastasis (95.9 %) was significantly better than that in the DYRK2-negative group (87.3 %, p = 0.015). These data show that DYRK2 expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence.


Breast cancer DYRK2 Prognostic factor 



The authors appreciate the technical support of Ms. Yoko Miyanari.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Yasuko Enomoto
    • 1
  • Shin-ichi Yamashita
    • 1
  • Yasuteru Yoshinaga
    • 1
  • Yasuyoshi Fukami
    • 1
  • So Miyahara
    • 1
  • Kazuki Nabeshima
    • 2
  • Akinori Iwasaki
    • 1
  1. 1.Department of General Thoracic, Breast, and Pediatric Surgery, Faculty of MedicineFukuoka UniversityFukuokaJapan
  2. 2.Department of Pathology, Faculty of MedicineFukuoka UniversityFukuokaJapan

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