Tumor Biology

, Volume 35, Issue 10, pp 10497–10502 | Cite as

Endothelial cell-specific molecule-1: a potential serum marker for gastric cancer

  • Zhongchuan Lv
  • Yongsheng Fan
  • Hongbing Chen
  • Dawei Zhao
Research Article


No ideal serum markers for gastric cancer (GC) screening have been identified. The aim of this study was to determine the usefulness of endothelial cell-specific molecule-1 (ESM-1) as a serum marker for GC. The ESM-1 levels in serum specimens from 114 patients with GC and 55 health subjects were measured using a sandwich ELISA kit. Receiver operating characteristic (ROC) curve was calculated to assess the diagnostic value of ESM-1. Survival curves by the Kaplan-Meier method were plotted to display overall survival distributions. Univariable and multivariable Cox regression analyses were performed to assess independent prognostic factors for overall survival in GC. We showed that the ESM-1 levels in the serum of patients with GC (83.7 ± 16.2 pg/mL) were significantly elevated compared to health subjects (44.7 ± 16.4 pg/mL). The accuracy, sensitivity, and specificity of ESM-1 for GC were 0.946, 98, and 80 %, respectively, by ROC curve analysis. The positive and negative predictive values were 91 and 93.6 %, respectively. The likelihood ratios of a positive or negative test result were 20.9 and 0.14, respectively. When analyzed with a Cox regression model, a higher serum ESM-1 level (≥84.2 pg/mL) was correlated with poor prognosis. This study suggests that serum ESM-1 level is increased in patients with GC and that ESM-1 can be used as a potential serum marker for early detection and prognosis evaluation of GC.


Endothelial cell-specific molecule-1 Gastric cancer Serum marker Early detection Prognosis 



No funding was received for the present study. We would like to thank Yifei Zhang for helping collecting the clinical data.

Conflicts of interest


Supplementary material

13277_2014_2319_Fig3_ESM.gif (60 kb)
Fig. S1

Serum concentration and receiver operating characteristics (ROC) curve of carcinoembryonic antigen (CEA). (a) Serum CEA levels in normal subjects (N) and in patients with GC. (b) Serum CEA levels in normal individuals (N), patients with early stage GC (stage I/II), and patients with late stage GC (stage III/IV). (c) The ROC curve for CEA in serum collected from patients with GC and health subjects. (GIF 59 kb)

13277_2014_2319_MOESM1_ESM.tif (1.3 mb)
High resolution image (TIFF 1.31 mb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Zhongchuan Lv
    • 1
  • Yongsheng Fan
    • 2
  • Hongbing Chen
    • 1
  • Dawei Zhao
    • 1
  1. 1.Department of Gastrointestinal SurgeryYantai Yuhuangding HospitalYantaiChina
  2. 2.Department of General SurgeryYantai Qixia People’s HospitalYantaiChina

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