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Tumor Biology

, Volume 35, Issue 10, pp 10195–10199 | Cite as

Clinical significance of serum ferritin in elderly patients with primary lung carcinoma

  • Mei Ji
  • Xiao-Dong Li
  • Hong-Bing Shi
  • Zhong-Hua Ning
  • Wei-Qing Zhao
  • Qi Wang
  • Li-Na Zhu
  • Yan Liu
  • Chang-Ping Wu
Research Article

Abstract

This study determined the levels of serum ferritin (SF) and carcinoembryonic antigen (CEA) in elderly patients with advanced primary lung cancer (PLC), and aimed to investigate the correlation between the SF level and clinical characteristics and compare the positive rates of SF and CEA levels in PLC patients and those in normal subjects. The SF and CEA levels of 69 elderly cases of advanced PLC and 63 elderly controls were determined by electrochemiluminescence method. The correlation between each independent clinicopathological characteristic and levels of SF and CEA was calculated. The positive rates of SF and CEA levels in PLC patients and those in normal subjects were compared. The results revealed that the level of SF in controls was significantly lower than those in patients with advanced LC (145.04 ± 141.77 vs. 293.57 ± 274.95 ng/ml, t = −3.845, P = 0.000). There was a statistically significant difference between SF level and gender, smoking, and regional lymph node metastasis, respectively (P < 0.05). The positive rate of SF combining with CEA was significantly higher than those of SF and CEA alone in patients with advanced PLC. High serum level of SF is helpful for diagnosing PLC in elderly patients and indicates poor prognosis.

Keywords

Serum ferritin Primary lung cancer Carcinoembryonic antigen 

Notes

Acknowledgments

This work was funded by grants from 2007’ The Twentieth Science and Technology Plan Supporting Projects of Changzhou provided by Yan Liu and The Jiangsu Health International Exchange Supporting Program provided by Xiao-Dong Li.

Conflicts of interest

The author(s) declare that they have no competing interests.

References

  1. 1.
    Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. 2011;61:212–36.CrossRefPubMedGoogle Scholar
  2. 2.
    Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: past, present and future. Biochim Biophys Acta. 1800;2010:760–9.Google Scholar
  3. 3.
    Kuvibidila SR, Gauthier T, Rayford W. Serum ferritin levels and transferrin saturation in men with prostate cancer. J Natl Med Assoc. 2004;96:641–9.PubMedCentralPubMedGoogle Scholar
  4. 4.
    Lorenzi M, Lorenzi B, Vernillo R. Serum ferritin in colorectal cancer patients and its prognostic evaluation. Int J Biol Markers. 2006;21:235–41.PubMedGoogle Scholar
  5. 5.
    Singh KJ, Singh SK, Suri A, Vijjan V, Goswami AK, Khullar M. Serum ferritin in renal cell carcinoma: effect of tumor size, volume grade, and stage. Indian J Cancer. 2005;42:197–200.PubMedGoogle Scholar
  6. 6.
    Inoue M, Minami M, Shiono H, Sawabata N, Ideguchi K, Okumura M. Clinicopathologic study of resected, peripheral, small-sized, non-small cell lung cancer tumors of 2 cm or less in diameter: pleural invasion and increase of serum carcinoembryonic antigen level as predictors of nodal involvement. J Thorac Cardiovasc Surg. 2006;131:988–93.CrossRefPubMedGoogle Scholar
  7. 7.
    Muley T, Dienemann H, Ebert W. CYFRA 21–1 and CEA are independent prognostic factors in 153 operated stage I NSCLC patients. Anticancer Res. 2004;24:1953–6.PubMedGoogle Scholar
  8. 8.
    Okada M, Nishio W, Sakamoto T, Uchino K, Yuki T, Nakagawa A, et al. Prognostic significance of perioperative serum carcinoembryonic antigen in non-small cell lung cancer: analysis of 1,000 consecutive resections for clinical stage I disease. Ann Thorac Surg. 2004;78:216–21.CrossRefPubMedGoogle Scholar
  9. 9.
    Sakao Y, Tomimitsu S, Takeda Y, Natsuaki M, Itoh T. Carcinoembryonic antigen as a predictive factor for postoperative tumor relapse in early-stage lung adenocarcinoma. Eur J Cardio-Thorac Surg: off J Eur Assoc Cardio-Thorac Surg. 2004;25:520–2.CrossRefGoogle Scholar
  10. 10.
    Hazard JT, Drysdale JW. Ferritinaemia in cancer. Nature. 1977;265:755–6.CrossRefPubMedGoogle Scholar
  11. 11.
    Milman N, Pedersen LM. The serum ferritin concentration is a significant prognostic indicator of survival in primary lung cancer. Oncol Rep. 2002;9:193–8.PubMedGoogle Scholar
  12. 12.
    Weinstein RE, Bond BH, Silberberg BK. Tissue ferritin concentration in carcinoma of the breast. Cancer. 1982;50:2406–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Kirkali Z, Guzelsoy M, Mungan MU, Kirkali G, Yorukoglu K. Serum ferritin as a clinical marker for renal cell carcinoma: influence of tumor size and volume. Urol Int. 1999;62:21–5.CrossRefPubMedGoogle Scholar
  14. 14.
    Kabat GC, Rohan TE. Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. Cancer Causes Control: CCC. 2007;18:1047–53.CrossRefPubMedGoogle Scholar
  15. 15.
    Kukulj S, Jaganjac M, Boranic M, Krizanac S, Santic Z, Poljak-Blazi M. Altered iron metabolism, inflammation, transferrin receptors, and ferritin expression in non-small-cell lung cancer. Med Oncol. 2010;27:268–77.CrossRefPubMedGoogle Scholar
  16. 16.
    Hansen HH, Hansen M. Tumor markers in small cell lung cancer. Eur J Cancer Clin Oncol. 1987;23:1585–7.CrossRefPubMedGoogle Scholar
  17. 17.
    Fracchia A, Ubbiali A, El Bitar O, Pacetti M, Sommariva E, Arreghini M, et al. A comparative study on ferritin concentration in serum and bilateral bronchoalveolar lavage fluid of patients with peripheral lung cancer versus control subjects. Oncology. 1999;56:181–8.CrossRefPubMedGoogle Scholar
  18. 18.
    Maria TG, Vasileios KE, Panagiotis PS, Kostas SN. Changes of acute-phase protein levels in the serum of lung cancer patients following radiotherapy. Int J Clin Exp Med. 2013;6:50–6.PubMedCentralPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Mei Ji
    • 1
  • Xiao-Dong Li
    • 1
  • Hong-Bing Shi
    • 1
  • Zhong-Hua Ning
    • 2
  • Wei-Qing Zhao
    • 1
  • Qi Wang
    • 1
  • Li-Na Zhu
    • 1
  • Yan Liu
    • 3
  • Chang-Ping Wu
    • 1
  1. 1.Department of OncologyThe Third Affiliated Hospital of Soochow UniversityChangzhouChina
  2. 2.Department of Radiation OncologyThe Third Affiliated Hospital of Soochow UniversityChangzhouChina
  3. 3.Department of HematologyThe Third Affiliated Hospital of Soochow UniversityChangzhouChina

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