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RETRACTED ARTICLE: Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis

Tumor Biology volume 35, pages 10137–10148 (2014)Cite this article

This article was retracted on 17 August 2015

Abstract

Cancer was viewed to be driven by accumulating genetic abnormalities that generally include chromosomal abnormalities, mutations in tumor-suppressor genes, and oncogenes. The aim of this meta-analysis was to systematically summarize the possible associations between MMP-13 rs2252070 A>G variant and cancer risks. We systematically reviewed studies focusing on MMP-13 polymorphisms with human cancer susceptibility that were published before April 30, 2014. Relevant articles were identified through research of PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CBM, and CNKI databases. All analyses were calculated using the Version 12.0 STATA software. Odds ratios (OR) and 95 % confidence interval (95 % CI) were calculated. Eleven independent case-control studies were included in the meta-analysis, which involved 3,465 patients with cancers and 4,073 healthy controls. The results identified a positive association between rs2252070 A>G polymorphism and susceptibility to cancer under five genetic models (all P < 0.05). Ethnicity subgroup analysis implied that significant difference was detected for rs2252070 A>G polymorphism with increased risk of cancers among Asians and Caucasians in majority of the groups. Our findings suggest significant association for MMP-13 rs2252070 A>G to increased susceptibility to human cancer, especially in the progression of lung carcinoma.

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Acknowledgments

We would like to acknowledge the helpful comments on this paper received from our reviewer.

Conflicts of interest

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Affiliations

  1. Department of Oncology, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China

    Ping Gao, Jun-Lan Yang & Yi Hu

  2. Department of Oncology, Hainan Branch of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China

    Hong Zhao & Jun-Hao You

Authors
  1. Ping Gao
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  2. Jun-Lan Yang
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  3. Hong Zhao
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  5. Yi Hu
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Correspondence to Yi Hu.

Additional information

Ping Gao and Jun-Lan Yang contributed equally to this work.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Gao, P., Yang, JL., Zhao, H. et al. RETRACTED ARTICLE: Common polymorphism in the MMP-13 gene may contribute to the risk of human cancers: a meta-analysis. Tumor Biol. 35, 10137–10148 (2014). https://doi.org/10.1007/s13277-014-2309-y

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  • DOI: https://doi.org/10.1007/s13277-014-2309-y

Keywords

  • MMP-13
  • Genetic polymorphism
  • Cancer
  • Meta-analysis