miR-141 targets ZEB2 to suppress HCC progression
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Increasing evidence suggests that microRNAs (miRNAs) are associated with HCC tumorigenesis. The present study was designed to define the role of miR-141 in HCC. The expression of miR-141 was significantly decreased in four HCC cell lines. Overexpression of miR-141 suppressed both the growth and the motility of HCC cells. Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. These data provide a novel potential therapeutic target for HCC treatment.
KeywordsHCC miR-141 ZEB2 Growth Motility
This work was funded by the Open Research Fund Program of the State Key Laboratory of Virology of China (2013003) and the Natural Science Foundation of Hubei Province (2010CDB08201).
Conflicts of interest
- 8.Liu YX, Long XD, Xi ZF, Ma Y, Huang XY, Yao JG, et al. MicroRNA-24 modulates aflatoxin b1-related hepatocellular carcinoma prognosis and tumorigenesis. Bio Med Research International. 2014;2014:482926.Google Scholar
- 9.9 Parpart S, Roessler S, Dong F, Rao V, Takai A, Ji J, Qin LX, Ye QH, Jia HL, Tang ZY, Wang XW: Modulation of mir-29 expression by alpha-fetoprotein is linked to the hepatocellular carcinoma epigenome. Hepatology 2014Google Scholar
- 10.10 Jiang HL, Yu H, Ma X, Xu D, Lin GF, Ma DY, Jin JZ: MicroRNA-195 regulates steroid receptor coactivator-3 protein expression in hepatocellular carcinoma cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014Google Scholar
- 11.11 Sheng Y, Li J, Zou C, Wang S, Cao Y, Zhang J, Huang A, Tang H: Downregulation of mir-101-3p by hepatitis b virus promotes proliferation and migration of hepatocellular carcinoma cells by targeting rab5a. Archives of virology 2014Google Scholar
- 15.Zhou J, Lu S, Yang S, Chen H, Shi H, Miao M, et al. MicroRNA-127 post-transcriptionally downregulates sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cellular physiology and biochemistry. Int J Experimental Cellular Physiol, Biochem, Pharmacol. 2014;33:1537–46.CrossRefGoogle Scholar
- 17.17 Wang W, Lin H, Zhou L, Zhu Q, Gao S, Xie H, Liu Z, Xu Z, Wei J, Huang X, Zheng S: MicroRNA-30a-3p inhibits tumor proliferation, invasiveness and metastasis and is downregulated in hepatocellular carcinoma. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2013Google Scholar
- 20.20 Banno K, Yanokura M, Iida M, Adachi M, Nakamura K, Nogami Y, Umene K, Masuda K, Kisu I, Nomura H, Kataoka F, Tominaga E, Aoki D: Application of microrna in diagnosis and treatment of ovarian cancer. BioMed research international 2014;2014:232817.Google Scholar
- 26.26 Techasen A, Namwat N, Loilome W, Duangkumpha K, Puapairoj A, Saya H, Yongvanit P: Tumor necrosis factor-alpha modulates epithelial mesenchymal transition mediators zeb2 and s100a4 to promote cholangiocarcinoma progression. Journal of hepato-biliary-pancreatic sciences 2014Google Scholar