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Tumor Biology

, Volume 35, Issue 10, pp 9993–9997 | Cite as

miR-141 targets ZEB2 to suppress HCC progression

  • Shi-Min Wu
  • Hong-Wu Ai
  • Ding-Yu Zhang
  • Xiao-Qun Han
  • Qin Pan
  • Feng-Ling Luo
  • Xiao-Lian Zhang
Research Article

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Increasing evidence suggests that microRNAs (miRNAs) are associated with HCC tumorigenesis. The present study was designed to define the role of miR-141 in HCC. The expression of miR-141 was significantly decreased in four HCC cell lines. Overexpression of miR-141 suppressed both the growth and the motility of HCC cells. Furthermore, we identified zinc finger E-box binding homeobox 2 (ZEB2) as a target of miR-141 and miR-141 functioned as a tumor suppressor via ZEB2 targeting in HCC. These data provide a novel potential therapeutic target for HCC treatment.

Keywords

HCC miR-141 ZEB2 Growth Motility 

Notes

Acknowledgments

This work was funded by the Open Research Fund Program of the State Key Laboratory of Virology of China (2013003) and the Natural Science Foundation of Hubei Province (2010CDB08201).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Shi-Min Wu
    • 1
    • 2
  • Hong-Wu Ai
    • 3
  • Ding-Yu Zhang
    • 2
  • Xiao-Qun Han
    • 2
  • Qin Pan
    • 1
  • Feng-Ling Luo
    • 1
  • Xiao-Lian Zhang
    • 1
  1. 1.State Key Laboratory of Virology, Department of Immunology, Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical SciencesWuhan UniversityWuhanChina
  2. 2.Department of Clinical laboratoryWuhan Medical Treatment CenterWuhanChina
  3. 3.Department of Clinical laboratoryWuhan Medical and Health Center for Women and ChildrenWuhanChina

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