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Tumor Biology

, Volume 35, Issue 10, pp 9893–9896 | Cite as

Prognostic effect of p53 expression in patients with completely resected colorectal cancer

  • Bin-Wei Liu
  • Yang Liu
  • Jun-Ru Liu
  • Zhong-Xu Feng
  • Tong Liu
Research Article

Abstract

The p53 protein is closely involved in the carcinogenesis of many kinds of cancers. Though the prognostic role of p53 expression for the survival of colorectal cancer (CRC) patients has been preliminarily identified, the prognostic effect of p53 expression in patients with completely resected CRC is still unclear. Therefore, a retrospective cohort study was performed to assess the prognostic role of p53 expression for overall survival in patients with completely resected CRC. A total of 153 patients (mean age 50.9 years) with completely resected CRC was finally included in the retrospective cohort study. Kaplan-Meier product-limit methods and log-rank test were used to estimate overall survival distribution and test the difference. In addition, multivariable analysis by Cox regression model was also used to test the prognostic role of p53 expression on overall survival by adjusting for other confounding factors. Of those 153 CRC patients, 62 (40.5 %) were positive for p53 protein expression in the tumor tissues. The log-rank test showed that there was an obvious difference in the overall survival between the p53-positive group and the p53-negative group (P < 0.001). Multivariable analysis by Cox regression model further showed that p53 protein expression was an independent predictor of shorter overall survival in patients with completely resected CRC (hazard ratio [HR] = 1.77; 95 % confidence interval [95 % CI] 1.15–2.71, P = 0.009). Therefore, p53 protein expression in the tumor tissue is an independent predictor of shorter overall survival in patients with completely resected CRC.

Keywords

Colorectal cancer p53 protein Prognosis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Bin-Wei Liu
    • 1
  • Yang Liu
    • 2
  • Jun-Ru Liu
    • 3
  • Zhong-Xu Feng
    • 2
  • Tong Liu
    • 1
  1. 1.Department of General SurgeryTianjin Medical University General HospitalTianjinChina
  2. 2.Department of General SurgeryQinhuangdao First HospitalQinhuangdaoChina
  3. 3.Department of EndocrinologyQinhuangdao First HospitalQinhuangdaoChina

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