Tumor Biology

, Volume 35, Issue 9, pp 9195–9200 | Cite as

Quantitative assessment of the associations between CD28 T > C polymorphism (rs3116496) and cancer risk

  • Jianjun Cong
  • Shulong Zhang
  • Xueren Gao
Research Article


Many studies have examined the association between CD28 T > C polymorphism (rs3116496) and cancer risk in various populations. However, results remained controversial. To assess this relationship more precisely, a meta-analysis was performed. A comprehensive literature search was performed using the PubMed database for relevant articles published (updated to January 1, 2014). Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association. A total of nine studies were selected for this meta-analysis, including 3,878 cases and 4,424 controls. The results indicated that CD28 T > C polymorphism (rs3116496) was not associated with the risk of cancer in overall population (CC + CT vs. TT, OR = 1.17, 95 %CI = 0.94–1.47, P H = 0.00; CC vs. CT + TT, OR = 1.26, 95 %CI = 0.92–1.73, P H = 0.86; CC vs. TT, OR = 1.27, 95 %CI = 0.92–1.74, P H = 0.85; CT vs. TT, OR = 1.15, 95 %CI = 0.91–1.46, P H = 0.00; and C vs. T, OR = 1.17, 95 %CI = 0.97–1.41, P H = 0.00). In subgroup analysis according to cancer type, no significant association was found in cervical cancer or other cancer. However, in the subgroup analysis by ethnicity, the significant risk was found among Asians (CC + CT vs. TT, OR = 1.51, 95 %CI = 1.24–1.83, P H = 0.05; C vs. T, OR = 1.46, 95 %CI = 1.22–1.74, P H = 0.11), but not among Caucasians. The result of this meta-analysis suggested that CD28 T > C polymorphism (rs3116496) may have an increased risk of cancer in Asians.


CD28 Polymorphism Cancer risk Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of NeurosurgeryAffiliated Zhongshan Hospital of Dalian UniversityDalianChina
  2. 2.Department of General Surgery, Zhongda HospitalMedical School of Southeast UniversityNanjingChina
  3. 3.Department of Microbiology and ImmunologyMedical School of Southeast UniversityNanjingChina

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