Tumor Biology

, Volume 36, Issue 3, pp 1429–1435 | Cite as

Clinicopathological significance of steroidogenic factor-1 expression in ovarian cancer versus ovarian sex cord stromal tumor

  • Zhuo-ying Hu
  • Liang-dan Tang
  • Hong-yu Zhang
  • Jing-ya Niu
  • Meng Lou
Research Article


The significance of steroidogenic factor-1 (SF-1) in human ovarian tumor has not been fully investigated. The purposes of this study are to provide a meta-analysis for SF-1 and to determine whether SF-1 is associated with ovarian tumor progression and clinicopathological characteristics. A detailed literature search was made for related research publications written in English. Methodological quality of the studies was also evaluated. The data were extracted and assessed by two reviewers independently. Analysis of pooled data was performed, and odds ratio (OR) and corresponding confidence intervals (CIs) were calculated and summarized respectively. Final analysis from seven eligible studies was performed. Aberrant SF-1 expression was significantly lower in ovarian cancer compared to that of normal ovarian tissue (OR = 0.02, 95 % CI = 0.00–0.16, p = 0.0002). However, SF-1 protein expression was not significantly different between benign and malignant ovarian tumors (p = 0.35). Interestingly, aberrant SF-1 expression was significantly higher in ovarian sex cord stromal tumors than that of ovarian cancer (OR = 0.00, 95 % CI = 0.00–0.01, p < 0.00001). The results of this meta-analysis suggest that SF-1 may play an important role in ovarian cancer initiation and progression. Moreover, SF-1 expression may serve as a marker in the differential diagnosis between ovarian sex cord stromal tumors and ovarian cancer.


Ovarian tumor Steroidogenic factor-1 Meta-analysis Diagnosis 



This work was funded by Natural Science Foundation in Chongqing City Health Bureau (No2012-2-015).


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Zhuo-ying Hu
    • 1
  • Liang-dan Tang
    • 1
  • Hong-yu Zhang
    • 2
  • Jing-ya Niu
    • 1
  • Meng Lou
    • 1
  1. 1.Department of Obstetrics and GynecologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina
  2. 2.Department of General SurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

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