Tumor Biology

, Volume 35, Issue 9, pp 8861–8866 | Cite as

miR-195 Targets HDGF to inhibit proliferation and invasion of NSCLC cells

  • Haizhou Guo
  • Weihao Li
  • Tianliang Zheng
  • Zhangsuo Liu
Research Article


Non-small cell lung cancer (NSCLC) is one of the most common causes of cancer-related death worldwide. MicroRNAs (miRNAs) play critical roles in the development and progression of NSCLC. miR-195 acts as a tumor suppressor in several cancers, however, its role in NSCLC is not well understood. Herein, we found that miR-195 was significantly decreased in both NSCLC tissues and cell lines. Forced expression of miR-195 significantly suppressed proliferation, migration, and invasion of NSCLC cells. Hepatoma-derived growth factor (HDGF) was identified as a target of miR-195 in NSCLC cells. Overexpression of HDGF dramatically abolished the tumor suppressive role of miR-195 in NSCLC cells. Our results demonstrated a tumor suppressive role of miR-195 in NSCLC, and suggested a potential therapeutic target for NSCLC.


NSCLC miR-195 HDGF Proliferation Migration Invasion 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Haizhou Guo
    • 1
  • Weihao Li
    • 1
  • Tianliang Zheng
    • 1
  • Zhangsuo Liu
    • 2
  1. 1.Department of Thoracic SurgeryThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  2. 2.Institute of NephrologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

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