Tumor Biology

, Volume 35, Issue 9, pp 9111–9117 | Cite as

Significance of estrogen receptor subtypes in breast tumorigenesis and progression

  • Weiliang Sun
  • Chijiang Gu
  • Minming Xia
  • Guoping Zhong
  • Haojun Song
  • Junming Guo
Research Article


The aim of the study was to investigate the effects of estrogen receptor (ER) subtypes (ERα and ERβ) on breast cancer development and progression. The expression level of ERα and ERβ in breast cancer tissues and paired normal breast tissues were detected by Western blot analysis and immunohistochemistry (IHC) staining. The features of ERα and ERβ status in cancer tissues or normal breast tissues and the correlations between clinicopathological characteristics and prognosis were analyzed. The expression levels of ERα and ERβ in breast cancer tissues are significantly lower than those in the paired normal tissues. The expression of ERβ is decreased more than that of ERα. ERα expression levels in cancer tissues are associated with tumor diameter, tumor–node–metastasis (TNM) stage, and progesterone receptor (PR) status. However, ERβ expression levels in cancer tissues are not correlated with clinicopathological factors of patients with breast cancer. In conclusion, ER subtypes might play different roles in the development of breast cancer.


Breast cancer Estrogen receptor ERα ERβ 



This work was supported by the Social Developmental Scientific Project of Yinzhou (No. 200553).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Ningbo Yinzhou People’s Hospital and the Affiliated HospitalNingbo University School of MedicineNingboChina
  2. 2.Ningbo No. 1 Hospital and the Affiliated HospitalNingbo University School of MedicineNingboChina
  3. 3.Department of Biochemistry and Molecular Biology, and Zhejiang Provincial Key Laboratory of PathophysiologyNingbo University School of MedicineNingboChina

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