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RETRACTED ARTICLE: Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

The molecular mechanism underlying the proliferation of colorectal cancer (CRC) cells is not completely understood. Here, we found that the level of neuregulin receptor degradation protein-1 (Nrdp1) E3 ubiquitin ligase was significantly decreased in CRC tissues, compared with the adjacent normal tissues from human patients. Knockdown of Nrdp1 enhanced the proliferation of CRC cells, while overexpression of Nrdp1 inhibited the proliferation of CRC cells. Further analysis showed that Nrdp1 may induce degradation of its target ErbB3 to inhibit activation of both ERK/MAPK and PI3K/Akt pathways in CRC cells, which seemed to affect cell proliferation via nuclear retention of a major cell-cycle inhibitor, p27. Taken together, these findings suggest that Nrdp1-mediated ErbB3 degradation suppresses cellular growth of CRC and that Nrdp1 loss in CRC may promote tumor progression, thus highlighting Nrdp1 as a novel target for CRC therapy.

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Acknowledgments

This work was supported by the internal funding of the First Affiliated Hospital, Liaoning Medical College, China.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, the First Affiliated Hospital, Liaoning Medical College, 5-2 People Road, Jinzhou, 121001, China

    Hang Lu, Dong Mao & Hongzhi Sun

  2. Department of Oncology, the First Affiliated Hospital, Liaoning Medical College, 5-2 People Road, Jinzhou, 121001, China

    Hua Li & Zhitu Zhu

Authors
  1. Hang Lu
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  2. Hua Li
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  3. Dong Mao
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  4. Zhitu Zhu
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  5. Hongzhi Sun
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Corresponding author

Correspondence to Hongzhi Sun.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Lu, H., Li, H., Mao, D. et al. RETRACTED ARTICLE: Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27. Tumor Biol. 35, 8639–8643 (2014). https://doi.org/10.1007/s13277-014-2132-5

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  • DOI: https://doi.org/10.1007/s13277-014-2132-5

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