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Tumor Biology

, Volume 35, Issue 9, pp 8659–8664 | Cite as

PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, inhibits anaplastic thyroid carcinoma cell proliferation and migration

  • Huan-yong Che
  • Hang-yuan Guo
  • Xu-wei Si
  • Qiao-ying You
  • Wei-ying Lou
Research Article

Abstract

The tyrosine and phosphoinositide kinases play crucial roles in the regulation of many cancer cell processes including cell survival and cell motility. Anaplastic thyroid carcinoma (ATC) is a rare and deadly type of thyroid cancer, and so far, there are no effective therapeutic compounds for ATC. Herein, we investigate the anticancer activities of PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, in ATC therapy. We found that PP121 is effective at suppressing cell viability, inducing cell apoptosis, and inhibiting cell migration and invasion. The potential anticancer mechanism for PP121 might be its inhibitory effects on phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in ATC cells. Furthermore, PP121 is effective at suppressing ATC tumor growth in vivo. In summary, our studies suggest that PP121 might be a promising therapeutic compound for ATC treatment, which might shed new light on ATC therapy.

Keywords

Anaplastic thyroid carcinoma PP121 Tyrosine Phosphoinositide kinase Proliferation Migration 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Huan-yong Che
    • 1
  • Hang-yuan Guo
    • 1
  • Xu-wei Si
    • 1
  • Qiao-ying You
    • 1
  • Wei-ying Lou
    • 1
  1. 1.Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang UniversityShaoxingPeople’s Republic of China

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