The prognosis significance of TGF-β1 and ER protein in cervical adenocarcinoma patients with stage Ib ~ IIa

Abstract

The incidence of stage Ib ~ IIa of cervical adenocarcinoma accounts about 60 to 70 % of all patients. This study aims to investigate the prognostic significance of protein estrogen receptor alpha (ERα) and transforming growth factor beta 1 (TGF-β1) level in different glandular epithelia of the cervix. In this study, immunohistochemistry was used to detect ERα and TGF-β1 in carcinomas and incisal margins of 66 cases with cervical adenocarcinoma, 20 cases with normal cervix, and 20 cases with chronic cervicitis. Uni- and multivariate analysis was applied to evaluate the prognostic significance of TGF-β1 and ERα in carcinomas. The results indicated that the positive expression of TGF-β1 in carcinomas was 71.21 %, significantly higher compared to that in the normal cervix (35 %) and chronic cervicitis (55 %) (χ 2 = 8.901, P = 0.012). Similarly, the positive expression of ERα in the carcinomas was 68.18 %, significantly higher compared to the normal cervix (35 %) and chronic cervicitis (50 %) (χ 2 = 7.693, P = 0.021). Both TGF-β1 and ERα in the carcinomas were associated with the vaginal recurrence, infection of HPV, depth of infiltration, and lymphatic metastasis (P < 0.05). The conjugation of TGF-β1 and ERα was an independent prognostic factor for cervical adenocarcinoma. Survival curve showed that the positive TGF-β1 and ERα indicated a short lifetime of patient with cervical adenocarcinoma. In conclusion, the expression of TGF-β1 and ERα protein in the carcinomas had a significant prognostic value in a patient of stage Ib ~ IIa in cervical adenocarcinoma.

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Correspondence to Xiao-Yu Tian.

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Fan, D., Tian, X., Wang, R. et al. The prognosis significance of TGF-β1 and ER protein in cervical adenocarcinoma patients with stage Ib ~ IIa. Tumor Biol. 35, 11237–11242 (2014). https://doi.org/10.1007/s13277-014-2110-y

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Keywords

  • ERα
  • TGF-β1
  • Cervical adenocarcinoma
  • Human papillomavirus
  • Prognosis