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Tumor Biology

, Volume 35, Issue 8, pp 8017–8022 | Cite as

CD243 gene polymorphism significantly associated with breast cancer susceptibility

  • Weirong Yao
  • Rongzeng Yan
  • Lin Ma
  • Huiping Wan
  • Yanmin Yu
  • Xia Cheng
  • Yingliang Li
Research Article

Abstract

We aimed to obtain a summary risk estimate for CD243 gene polymorphism associated with breast cancer. A total of nine case–control studies, including 5,073 cancer patients and 7,498 control subjects, were pooled in our fixed effects meta-analysis of the association between CD243 gene polymorphism and risk of breast cancer. All data were analyzed by using Stata software (version 12.0). We found significant risk effects under TT vs. TC + CC genetic model [odds ratio (OR) = 1.09, 95 % confidence interval (CI) = 1.01–1.18, P = 0.516], but not in other comparisons. Stratifying the pooled data by ethnicity and source of controls revealed that the association between the T allele and an increased risk of breast cancer was more pronounced among Asians (TT vs. CC: OR = 1.26, 95 % CI = 1.02–1.57, P = 0.720; TT vs. TC + CC: OR = 1.31, 95 % CI = 1.07–1.61, P = 0.708) and hospital-based studies (TT vs. CC: OR = 1.25, 95 % CI = 1.02–1.53, P = 0.877; TT vs. TC + CC: OR = 1.27, 95 % CI = 1.05–1.53, P = 0.540). No notable heterogeneity was indicated across studies. Our meta-analysis demonstrates that CD243 gene polymorphism may act as a predisposition factor for breast cancer, particularly in Asian populations.

Keywords

CD243 polymorphism Breast cancer Risk 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Radiation OncologyChinese PLA General HospitalBeijingChina
  2. 2.Department of OncologyPeople’s Hospital of Jiangxi ProvinceNanchangChina
  3. 3.Chinese People’s Armed Police Forces Jiangxi General HospitalNanchangChina
  4. 4.Department of General SurgeryThe First Affiliated Hospital of Nanchang UniversityNanchangChina

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