The ATP7B genetic polymorphisms predict clinical outcome to platinum-based chemotherapy in lung cancer patients
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This study aims to investigate the influence of ATP7B genetic polymorphism to platinum-based chemotherapy in Chinese Han lung cancer patients. A total of 338 Chinese Han lung cancer patients were enrolled in this study. All patients underwent at least two cycles of platinum-based chemotherapy. Four tag SNPs of ATP7B (rs1061472, rs9535826, rs7999812, and rs9535828) were selected to evaluate their impacts to platinum-based chemotherapy in these patients. ATP7B rs9535828 and rs9535826 were found to be associated with platinum resistance in Chinese Han lung cancer patients. Patients with A allele in ATP7B rs9535828 presented an increased susceptibility to platinum drugs (OR 1.96, 95 % CI 1.17–3.30, p < 0.01). Patients with G allele in ATP7B rs9535826 had the highest susceptibility to platinum drugs (OR 2.05, 95 % CI 1.19–3.52, p < 0.01). Our findings suggest that ATP7B genetic polymorphisms could affect the therapeutic efficacy of platinum-based chemotherapy, and ATP7B gene might be considered as predictive markers for the efficacy evaluation of platinum-based chemotherapy in Chinese Han lung cancer patients.
KeywordsATP7B Polymorphism Lung cancer Platinum Chemotherapy Efficacy
We thank all subjects who volunteered to participate in this study. This work was supported by the National High-tech R&D Program of China (863 Program) (2012AA02A517), National Natural Science Foundation of China (81173129, 81202595, 81373490), Program for the Special Scientific Research Foundation of Doctor Disciplines in University of Ministry of Education of China (20110162110034), Hunan Provincial Natural Science Foundation of China (12JJ7006), and Hunan Provincial Science and Technology Plan Projects (2011TT2025, 2012TT2021).
Conflicts of interest
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