Tumor Biology

, Volume 35, Issue 7, pp 6193–6194 | Cite as

Comment on Xu XW et al.: prognostic significance of VEGF expression in osteosarcoma: a meta-analysis

  • Shaozhong He
  • Zhenyu Xiao
  • Longhua Chen
  • Shizhong Xiong
Research Commentary


Vascular Endothelial Growth Factor Cancer Research Observational Study Osteosarcoma Quality Assessment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Yu XW, Wu TY, Yi X, Ren WP, Zhou ZB, Sun YQ, et al. Prognostic significance of VEGF expression in osteosarcoma: a meta-analysis. Tumor Biol. 2014;35(1):155–60.CrossRefGoogle Scholar
  2. 2.
    Lee YH, Tokunaga T, Oshika Y, et al. Cell-retained isoforms of vascular endothelial growth factor (VEGF) are correlated with poor prognosis in osteosarcoma. Eur J Cancer. 1999;35(7):1089–93.CrossRefPubMedGoogle Scholar
  3. 3.
    Kaya M, Wada T, Akatsuka T, et al. Vascular endothelial growth factor expression in untreated osteosarcoma is predictive of pulmonary metastasis and poor prognosis. Clin Cancer Res. 2000;6(2):572–7.PubMedGoogle Scholar
  4. 4.
    Jung ST, Moon ES, Seo HY, Kim JS, Kim GJ, Kim YK. Expression and significance of TGF-beta isoform and VEGF in osteosar-coma. Orthopedics. 2005;28(8):755–60.PubMedGoogle Scholar
  5. 5.
    Charity RM, Foukas AF, Deshmukh NS, Grimer RJ. Vascular endothelial growth factor expression in osteosarcoma. Clin Orthop Relat Res. 2006;448:193–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Oda Y, Yamamoto H, Tamiya S, et al. CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis. Mod Pathol. 2006;19(5):738–45.CrossRefPubMedGoogle Scholar
  7. 7.
    Kaya M, Wada T, Nagoya S, Sasaki M, Matsumura T, Yamashita T. The level of vascular endothelial growth factor as a predictor of a poor prognosis in osteosarcoma. J Bone Joint Surg Br. 2009;91(6):784–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Ługowska I, Woźniak W, Klepacka T, Michalak E, Szamotulska K. A prognostic evaluation of vascular endothelial growth factor in children and young adults with osteosarcoma. Pediatr Blood Cancer. 2011;57(1):63–8.CrossRefPubMedGoogle Scholar
  9. 9.
    Chen Y, Wang CM, Shi YQ, Yang Y. Expression of hypoxiainducible factor 1α in osteosarcoma and its value in predicting chemosensitivity [in Chinese]. Chin J Oncol. 2012;34(12):899–904.Google Scholar
  10. 10.
    Boulytcheva IV, Soloviev YN, Kushlinskii NE, Mahson AN. Expression of molecular markers in the tumor and survival prognosis in osteosarcoma. Bull Exp Biol Med. 2010;150(2):237–42.CrossRefPubMedGoogle Scholar
  11. 11.
    Handa A, Tokunaga T, Tsuchida T, et al. Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. Int J Oncol. 2000;17(2):291–5.PubMedGoogle Scholar
  12. 12.
    Ek ET, Ojaimi J, Kitagawa Y, Choong PF. Does the degree of intratumoural microvessel density and VEGF expression have prognostic significance in osteosarcoma. Oncol Rep. 2006;16(1):17–23.PubMedGoogle Scholar
  13. 13.
    Abdeen A, Chou AJ, Healey JH, et al. Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma. Cancer. 2009;115(22):5243–50.CrossRefPubMedGoogle Scholar
  14. 14.
    Zhou Q, Zhu Y, Deng Z, Long H, Zhang S, Chen X. VEGF and EMMPRIN expression correlates with survival of patients with osteosarcoma. Surg Oncol. 2011;20(1):13–9.CrossRefPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Shaozhong He
    • 1
    • 2
  • Zhenyu Xiao
    • 1
  • Longhua Chen
    • 2
  • Shizhong Xiong
    • 1
  1. 1.Department of OncologyGanzhou People’s HospitalGanzhouPeople’s Republic of China
  2. 2.Department of OncologyNanfang Hospital of Southern Medical UniversityGuangzhouPeople’s Republic of China

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