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miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3

Tumor Biology volume 35, pages 10759–10764 (2014)Cite this article

Abstract

MicroRNAs (miRNAs) play essential roles in the progression of hepatocellular carcinoma (HCC). miR-144 acts as a tumor suppressor in some malignancies, while its role in HCC is unclear. Here, we found that miR-144 was significantly decreased in HCC tissues and cell lines. Forced overexpression of miR-144 remarkably reduced cell proliferation, increased apoptosis, and suppressed migration and invasion of HCC cells. E2F transcription factor 3 (E2F3) was identified as a target of miR-144 in HCC cells. Moreover, E2F3 overexpression partially attenuated the tumor suppressive effects of miR-144, and the expression of E2F3 was negatively correlated with miR-144 level in HCC tissues. Our data suggest that miR-144 might suppress the growth and motility of HCC cells partially by targeting E2F3.

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Affiliations

  1. Department of General Surgery, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, 430070, China

    Tingjia Cao, Hanjun Li, Yilin Hu, Dandan Ma & Xun Cai

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  1. Tingjia Cao
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  2. Hanjun Li
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  3. Yilin Hu
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  4. Dandan Ma
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  5. Xun Cai
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Correspondence to Hanjun Li.

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Cao, T., Li, H., Hu, Y. et al. miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3. Tumor Biol. 35, 10759–10764 (2014). https://doi.org/10.1007/s13277-014-2017-7

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  • DOI: https://doi.org/10.1007/s13277-014-2017-7

Keywords

  • miR-144
  • Hepatocellular carcinoma
  • Growth
  • Growth
  • Migration
  • Invasion
  • E2F3