Tumor Biology

, Volume 35, Issue 7, pp 6941–6948 | Cite as

High serum transforming growth factor beta 1 (TGFB1) level predicts better survival in breast cancer

  • Rumeysa Ciftci
  • Faruk Tas
  • Ceren Tilgen Yasasever
  • Ece Aksit
  • Senem Karabulut
  • Fatma Sen
  • Serkan Keskin
  • Leyla Kilic
  • İbrahim Yildiz
  • Hamza Ugur Bozbey
  • Derya Duranyildiz
  • Sezai Vatansever
Research Article


The transforming growth factor beta 1 (TGFB1) is a regulatory cytokine with both tumor suppressor and tumor-promoting effects in breast cancer (BC) cell lines and tissue. Data about level of circulating TGFB1 and its prognostic significance in BC patients is conflicting. The objective of this study is to determine the clinical significance of the serum TGFB1 levels in BC patients. We enrolled 96 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum TGFB1 levels were measured by ELISA method and compared with 30 healthy controls. The mean serum TGFB1 level of BC patients was significantly higher than controls (0.08 vs. 0.04 ng/ml, p < 0.001). There was no significant difference according to known disease-related clinicopathological or laboratory parameters. Serum TGFB1 level had a significant impact on overall survival in both univariate (p = 0.01) and multivariate analysis (p = 0.013). Serum TGFB1 level is elevated in BC patients and has a favorable prognostic value. However, it has no predictive role on CT response.


Breast cancer Prognostic Serum TGFB1 level 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Rumeysa Ciftci
    • 1
  • Faruk Tas
    • 1
  • Ceren Tilgen Yasasever
    • 2
  • Ece Aksit
    • 2
  • Senem Karabulut
    • 1
  • Fatma Sen
    • 1
  • Serkan Keskin
    • 1
  • Leyla Kilic
    • 1
  • İbrahim Yildiz
    • 1
  • Hamza Ugur Bozbey
    • 1
  • Derya Duranyildiz
    • 2
  • Sezai Vatansever
    • 1
  1. 1.Medical Oncology Department, Institute of OncologyIstanbul UniversityIstanbulTurkey
  2. 2.Basic Oncology Department, Institute of OncologyIstanbul UniversityIstanbulTurkey

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