Many studies have evaluated the association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer susceptibility. However, these studies showed inconsistent results. The aim of this study was to derive a more precise estimation of this association. We searched PubMed and Embase for related studies that had been published in English, and ten case–control studies with a total of 2,864 cases and 3,898 controls were finally identified to be eligible studies in the meta-analysis. The association was assessed by summarizing the odds ratios (ORs) with the corresponding 95 % confidence intervals (CIs). Overall, there was no significant association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer risk (for the allele model A vs. G: OR = 1.02, 95 % CI 0.88–1.19, p = 0.76; for the co-dominant model AA vs. GG: OR = 1.03, 95 % CI 0.75–1.41, p = 0.85; for the dominant model AA + GA vs. GG: OR = 1.00, 95 % CI 0.78–1.28, p = 0.99; for the recessive comparison AA vs. GA + GG: OR = 1.06, 95 % CI 0.85–1.32, p = 0.62). In subgroup analysis by ethnicity, no significant difference was found in both Asians and Caucasians. In summary, the present meta-analysis provides evidence that genotypes for the cyclin D1 (CCND1) G870A polymorphism may be not associated with genetic susceptibility of cervical cancer.
Cyclin D1 Polymorphism Cervical cancer Meta-analysis
This is a preview of subscription content, log in to check access.
This work was supported by the National Natural Sciences Foundation of China (No. 81272334).
Hall M, Peters G. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res. 1996;68:67–108.CrossRefPubMedGoogle Scholar
Betticher DC, Thatcher N, Altermatt HJ, Hoban P, Ryder WD, Heighway J. Alternate splicing produces a novel cyclin D1 transcript. Oncogene. 1995;11(5):1005–11.PubMedGoogle Scholar
Lu F, Gladden AB, Diehl JA. An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. Cancer Res. 2003;63(21):7056–61.PubMedGoogle Scholar
Wang N, Qian X, Wang S, Gao H, Wang L, Huo Y, et al. CCND1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in Chinese population. Mol Carcinog. 2012;51(2):196–205. doi:10.1002/mc.20801.CrossRefPubMedGoogle Scholar
Catarino R, Pereira D, Breda E, Coelho A, Matos A, Lopes C, et al. Oncogenic virus-associated neoplasia: a role for cyclin D1 genotypes influencing the age of onset of disease? Biochem Biophys Res Commun. 2008;370(1):118–22. doi:10.1016/j.bbrc.2008.03.039.CrossRefPubMedGoogle Scholar
Thakur N, Hussain S, Kohaar I, Tabassum R, Nasare V, Tiwari P, et al. Genetic variant of CCND1: association with HPV-mediated cervical cancer in Indian population. Biomark: Biochem Indic Expo Response Susceptibility Chem. 2009;14(4):219–25. doi:10.1080/13547500902825274.CrossRefGoogle Scholar
Castro FA, Haimila K, Sareneva I, Schmitt M, Lorenzo J, Kunkel N, et al. Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population–a candidate gene approach. Int J Cancer J Int Du Cancer. 2009;125(8):1851–8. doi:10.1002/ijc.24529.CrossRefGoogle Scholar
Francisco G, Menezes PR, Eluf-Neto J, Chammas R. Arg72Pro TP53 polymorphism and cancer susceptibility: a comprehensive meta-analysis of 302 case-control studies. Int J Cancer J Int Du Cancer. 2011;129(4):920–30. doi:10.1002/ijc.25710.CrossRefGoogle Scholar
Castro FA, Ivansson EL, Schmitt M, Juko-Pecirep I, Kjellberg L, Hildesheim A, et al. Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility. Int J Cancer J Int Du Cancer. 2012;130(2):349–55. doi:10.1002/ijc.26016.CrossRefGoogle Scholar
Zhou C, An H, Hu M, Liu Q, Geng P, Xu J, et al. The cyclin D1 (CCND1) G870A polymorphism and lung cancer susceptibility: a meta-analysis. Tumour Biol: J Int Soc Oncodevelop Biol Med. 2013. doi:10.1007/s13277-013-0968-8.Google Scholar
Zhang LQ, Wang J, Shang JQ, Bai JL, Liu FY, Guan X, et al. Cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a meta-analysis of 20 populations. Int J Color Dis. 2011;26(10):1249–55. doi:10.1007/s00384-011-1220-x.CrossRefGoogle Scholar