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Association of endothelia nitric oxide synthase gene rs1799983 polymorphism with susceptibility to prostate cancer: a meta-analysis

Tumor Biology volume 35, pages 7057–7062 (2014)Cite this article

Abstract

Genetic polymorphism of endothelial nitric oxide synthase (NOS3) rs1799983 (Glu298Asp) has been implicated to alter the risk of prostate cancer, but the results are controversial. Two investigators independently searched the PubMed, Cochrane Library, and Embase electronic databases up to September 30, 2013. Summary odds ratios (OR) and 95 % confidence interval (CI) for rs1799983 polymorphism and prostate cancer were calculated. Statistical analysis was performed with the software program Review Manage, version 5.0 and Stata 11.0. A total of 7 independent studies, including 1,792 cases and 2,411 controls, were identified. Our analysis suggested that rs1799983 was associated with prostate cancer risk in overall population under dominant model (OR = 1.15, 95%CI = 1.01–1.30, P = 0.03) and allelic model (OR = 1.11, 95%CI = 1.00–1.22, P = 0.04). In the subgroup analysis, we detected no association between rs1799983 polymorphism and prostate risk in Caucasian population under all the genetic models. This meta-analysis showed the evidence that NOS3 rs1799983 polymorphism was associated with a risk of prostate cancer development in overall populations.

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Abbreviations

NOS3:

Endothelial nitric oxide synthase, also abbreviate as eNOS

PCa:

Prostate cancer

OR:

Odds ratio

CI:

Confidence interval

vs:

Versus

R:

Random effect model

F:

Fixed effect model

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Acknowledgments

This study was supported by Tianjin Science Technology Project. (No. 12ZCDZSY16300)

Conflicts of interest

None

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Affiliations

  1. Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, No.23, Pingjiang Road, Tianjin, China, 300211

    Jian Hui Wu, Kuo Yang & Yong Xu

  2. Department of Urology, Tianjin First Center Hospital, No.24, Fukang Road, Tianjin, China, 300192

    Hong Shun Ma

Authors
  1. Jian Hui Wu
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  2. Kuo Yang
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  3. Hong Shun Ma
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  4. Yong Xu
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Correspondence to Yong Xu.

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Wu, J.H., Yang, K., Ma, H.S. et al. Association of endothelia nitric oxide synthase gene rs1799983 polymorphism with susceptibility to prostate cancer: a meta-analysis. Tumor Biol. 35, 7057–7062 (2014). https://doi.org/10.1007/s13277-014-1870-8

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  • DOI: https://doi.org/10.1007/s13277-014-1870-8

Keywords

  • Nitric Oxide
  • Prostate Cancer
  • Publication Bias
  • Rs1799983 Polymorphism
  • Prostate Cancer Risk