Tumor Biology

, Volume 35, Issue 7, pp 6867–6877 | Cite as

RETRACTED ARTICLE: Correlations of IFN-γ genetic polymorphisms with susceptibility to breast cancer: a meta-analysis

  • Chun-Jiang Li
  • Yue Dai
  • Yan-Jun Fu
  • Jia-Ming Tian
  • Jin-Lun Li
  • Hong-Jun Lu
  • Feng Duan
  • Qing-Wang Li
Research Article


The meta-analysis was conducted to evaluate the correlations between common genetic polymorphisms in the IFN-γ gene and susceptibility to breast cancer. The following electronic databases were searched without language restrictions: MEDLINE (1966 ~ 2013), the Cochrane Library Database (issue 12, 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), Web of Science (1945 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). Meta-analysis was performed with the use of the STATA statistical software. Odds ratios (OR) with their 95 % confidence intervals (95 % CIs) were calculated. Nine clinical case-control studies met all the inclusion criteria and were included in this meta-analysis. A total of 1,182 breast cancer patients and 1,525 healthy controls were involved in this meta-analysis. Three functional polymorphisms were assessed, including rs2069705 C>T, rs2430561 T>A, and CA repeats 2/X. Our meta-analysis results indicated that IFN-γ genetic polymorphisms might be significantly associated with an increased risk of breast cancer (allele model: OR = 1.37, 95 % CI = 1.03 ~ 1.83, P = 0.031; dominant model: OR = 1.55, 95 % CI = 1.01 ~ 2.37, P = 0.046; homozygous model: OR = 2.23, 95 % CI = 1.30 ~ 3.82, P = 0.004; respectively), especially the rs2430561 T>A polymorphism. Subgroup analysis based on ethnicity suggested that genetic polymorphisms in the IFN-γ gene were closely correlated with increased breast cancer risk among Asians (allele model: OR = 1.21, 95 % CI = 1.02 ~ 1.58, P = 0.017; dominant model: OR = 3.44, 95 % CI = 2.07 ~ 5.71, P < 0.001; recessive model: OR = 1.58, 95 % CI = 1.06 ~ 2.37, P = 0.025; homozygous model: OR = 1.83, 95 % CI = 1.19 ~ 2.80, P = 0.006; respectively), but not among Caucasians (all P > 0.05). Our meta-analysis supported the hypothesis that IFN-γ genetic polymorphisms may contribute to an increased risk of breast cancer, especially the rs2430561 T>A polymorphism among Asians.


IFN-γ Genetic polymorphism Susceptibility Breast cancer Meta-analysis 



This work was supported by the Natural Science Foundation of Heilongjiang Province (No. D201166). We would like to acknowledge the reviewers for their helpful comments on this paper.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Chun-Jiang Li
    • 1
    • 2
  • Yue Dai
    • 2
  • Yan-Jun Fu
    • 3
  • Jia-Ming Tian
    • 3
  • Jin-Lun Li
    • 4
  • Hong-Jun Lu
    • 3
  • Feng Duan
    • 4
  • Qing-Wang Li
    • 1
    • 5
  1. 1.College of Environment and Chemical EngineeringYanshan UniversityQinhuangdaoPeople’s Republic of China
  2. 2.College of Basic MedicineJiamusi UniversityJiamusiPeople’s Republic of China
  3. 3.The First Affiliated Hospital of Jiamusi UniversityJiamusiPeople’s Republic of China
  4. 4.The Second Affiliated Hospital of Jiamusi UniversityJiamusiPeople’s Republic of China
  5. 5.College of Animal ScienceNorthwest A&F UniversityYanglingPeople’s Republic of China

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