Tumor Biology

, Volume 35, Issue 6, pp 5895–5904 | Cite as

CCL5-403, CCR5-59029, and Delta32 polymorphisms and cancer risk: a meta-analysis based on 20,625 subjects

  • Houqun Ying
  • Jie Wang
  • Xueren Gao
Research Article


Associations between CCL5-403, CCR5-59029, and Delta32 polymorphisms and cancer risk are inconclusive. To derive a more precise estimation of the association, we performed a meta-analysis by searching PubMed, EMBASE, Google scholar, and WanFang databases. A total of 20 eligible articles with 39 studies were included. Of those studies, there were 21 studies for CCR5-Delta32 polymorphism, 9 studies for CCR5-59029 polymorphism, and 9 studies for CCL5-403 polymorphism. Combined analysis revealed no associations between these polymorphisms and cancer risk. However, subgroup analysis by ethnicity suggested that CCR5-59029 polymorphism was associated with the risk of cancer among Asian populations (A vs. G: odds ratio (OR) = 1.36, 95 % confidence interval (CI) 1.13–1.65, P H = 0.27; AA vs. GG: OR = 2.07, 95 % CI 1.37–3.12, P H = 0.17; GA+AA vs. GG: OR = 1.35, 95 % CI 1.03–1.77, P H = 0.92; AA vs. GA+GG: OR = 1.98, 95 % CI 1.01–3.88, P H = 0.08), but not among Caucasian populations. CCL5-403 polymorphism was associated with the risk of cancer among African populations (A vs. G: OR = 0.68, 95 % CI 0.55–0.83, P H = 0.14; AA vs. GG: OR = 0.51, 95 % CI 0.33–0.77, P H = 0.52; AG vs. GG: OR = 0.58, 95 % CI 0.42–0.80, P H = 0.14; AG+AA vs. GG: OR = 0.56, 95 % CI 0.41–0.75, P H = 0.13), but not among Caucasian populations and Asian populations. Overall, this meta-analysis indicated that CCR5-Delta32 was not associated with the risk of cancer. CCR5-59029 polymorphism contributed to cancer risk among Asian populations, and CCL5-403 polymorphism was associated with the decreased risk of cancer among African populations.


CCL5 CCR5 Polymorphism Cancer Meta-analysis 


Conflicts of interest


Supplementary material

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ESM 1 (PDF 17 kb)
13277_2014_1780_MOESM2_ESM.pdf (16 kb)
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13277_2014_1780_MOESM3_ESM.pdf (15 kb)
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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Clinical LaboratoryMedical College of Southeast UniversityNanjingChina
  2. 2.Key Laboratory of Developmental Genes and Human Disease, Ministry of EducationSoutheast UniversityNanjingChina
  3. 3.Department of Microbiology and ImmunologyMedical College of Southeast UniversityNanjingChina

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