Tumor Biology

, Volume 35, Issue 6, pp 5583–5588 | Cite as

Cleft lip and palate transmembrane protein 1 rs31489 polymorphism is associated with lung cancer risk: a meta-analysis

  • Yuansheng Zang
  • Wei Nie
  • Zheng Fang
  • Bing Li
Research Article


The potentially functional polymorphism, rs31489, in the promoter region of cleft lip and palate transmembrane protein 1 (CLPTM1L) gene has been implicated in cancer risk. However, individual published studies showed inconclusive results. To obtain a more precise estimate of the association between CLPTM1L rs31489 and risk of lung cancer, we performed a meta-analysis. Summary odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were estimated using random-effects models. Ten individual case–control studies in eight publications with 20,680 cases and 28,330 controls were included. Overall, the variant genotypes were associated with a significantly increased lung cancer risk in different genetic models (CC + AC vs. AA: OR = 1.20, 95 % CI 1.12–1.28, P < 0.001; CC vs. AC + AA: OR = 1.15, 95 % CI 1.07–1.23, P < 0.001; CC vs. AA: OR = 1.28, 95 % CI 1.17–1.41, P < 0.001; CC vs. AC: OR = 1.11, 95 % CI 1.05–1.17, P < 0.001; C vs. A: OR = 1.12, 95 % CI 1.06–1.18, P < 0.001). In the stratified analyses, the increased lung risk remained for the studies of Caucasian populations. In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.


Lung cancer CLPTM1L Meta-analysis Polymorphism 



This work was supported by the National Natural Science Foundation of China (No. 30900660, 81172227) and Science and Technology Commission of Shanghai Municipality (No. 09dz1976000, 124119a5800).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Respiratory Medicine, Shanghai Changzheng HospitalSecond Military Medical UniversityShanghaiChina

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