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PL-1. Opening lecture: Clinical impact of genome sequencing in lymphoid neoplasms
Campo E (firstname.lastname@example.org)
Hospital Clinic. Barcelona, Spain
Lymphoid neoplasms are a heterogeneous group of tumors with different clinical manifestations and evolution. The genetic and molecular mechanisms are not well understood. The systematic application of next generation sequencing technologies in these tumors have provided the first comprehensive view of somatic mutations revealing a remarkable molecular heterogeneity. Chronic lymphocytic leukemia (CLL) is the most frequent leukemia of adults in the Western countries. Genomic studies have revealed a remarkable molecular heterogeneity with only few genes mutated in up to 10-15% of the patients and a relatively large number of genes recurrently mutated at low frequency. The mutated genes tend to cluster in different pathways that include NOTCH1 signaling, RNA splicing, processing and transport machinery, innate inflammatory response, telomere...