Advertisement

Tumor Biology

, Volume 35, Supplement 1, pp 1–19 | Cite as

Plenary Lectures

Abstracts
  • 250 Downloads

PL-1. Opening lecture: Clinical impact of genome sequencing in lymphoid neoplasms

Campo E (ecampo@clinic.ub.es)

Hospital Clinic. Barcelona, Spain

Lymphoid neoplasms are a heterogeneous group of tumors with different clinical manifestations and evolution. The genetic and molecular mechanisms are not well understood. The systematic application of next generation sequencing technologies in these tumors have provided the first comprehensive view of somatic mutations revealing a remarkable molecular heterogeneity. Chronic lymphocytic leukemia (CLL) is the most frequent leukemia of adults in the Western countries. Genomic studies have revealed a remarkable molecular heterogeneity with only few genes mutated in up to 10-15% of the patients and a relatively large number of genes recurrently mutated at low frequency. The mutated genes tend to cluster in different pathways that include NOTCH1 signaling, RNA splicing, processing and transport machinery, innate inflammatory response, telomere...

Keywords

Epidermal Growth Factor Receptor Prostate Specific Antigen Epidermal Growth Factor Receptor Mutation Uveal Melanoma Faecal Immunochemical Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Personalised recommendations