Tumor Biology

, Volume 35, Issue 6, pp 5449–5452 | Cite as

Aberrant BLID expression is associated with breast cancer progression

  • Xiaoyan Li
  • Peng Su
  • Xianqiang Liu
  • Xiangnan Kong
  • Xin Zhang
  • Hongyu Zhang
  • Qifeng Yang
Research Article


In our previous study, we have found that BH3-like motif containing, cell death inducer (BLID) was a tumor suppressor in breast cancer, and its downregulation was correlated with both poor disease-free and overall survival. In the present study, we aimed to explore the possible role of BLID in breast cancer progression. We found that BLID was strongly expressed in all normal breast tissues, and it became lower and wreaker gradually in the progression from normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), and DCIS (ductal carcinoma in situ) to breast cancer. Statistical analysis demonstrated significant different BLID expressions between proliferative and cancerous breast lesions. Our data suggested that loss of BLID may contribute to the progression of intraductal proliferation lesions to breast cancer. Our finding gives a new clue that BLID might be a potential indicator for progression of breast cancer in the future.


BLID Breast cancer Progression 



This work was supported by National Natural Science Foundation of China (No. 81072150; No. 81172529; No. 81272903) and Shandong Science and Technology Development Plan (No. 2012GZC22115).

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xiaoyan Li
    • 1
  • Peng Su
    • 2
  • Xianqiang Liu
    • 3
  • Xiangnan Kong
    • 1
  • Xin Zhang
    • 1
  • Hongyu Zhang
    • 1
  • Qifeng Yang
    • 1
    • 4
  1. 1.Department of Breast SurgeryQilu Hospital, Shandong UniversityJinanPeople’s Republic of China
  2. 2.Department of PathologyQilu Hospital, Shandong UniversityJinanPeople’s Republic of China
  3. 3.Department of SurgeryAffiliated Jinan Central Hospital of Shandong UniversityJinanPeople’s Republic of China
  4. 4.Department of Pathology Tissue BankQilu Hospital, Shandong UniversityJinanPeople’s Republic of China

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