Tumor Biology

, Volume 35, Issue 6, pp 5287–5293 | Cite as

Down-regulation of miR-150 induces cell proliferation inhibition and apoptosis in non-small-cell lung cancer by targeting BAK1 in vitro

  • Xiao-yan Gu
  • Jun Wang
  • Yi-zhou Luo
  • Qiang Du
  • Ruo-ran Li
  • Hui Shi
  • Tian-pei Yu
Research Article

Abstract

Non-small-cell lung cancer (NSCLC) is one of the most common causes of cancer-related death. Our investigations show that miR-150 is a typical microRNA that is overexpressed in human NSCLC. We characterized the effects of miR-150 overexpression in NSCLC cells and found that down-regulation of miR-150 expression inhibited cell proliferation and induced cell apoptosis in vitro; additionally, up-regulation of miR-150 levels had the opposite effect on tumor growth and progression. Furthermore, we found that the mechanism of the miR-150 effects on NSCLC cells was associated with alterations in the expression of human BRI1-associated receptor kinase 1 (BAK1). miR-150 may function as an oncogene in NSCLC cells by directly targeting BAK1. Thus, these data highlight a novel molecular interaction between miR-150 and BAK1 and provide a novel strategy for NSCLC therapy via the down-regulation of miR-150 expression.

Keywords

miR-150 Proliferation Apoptosis Non-small-cell lung cancer 

Notes

Acknowledgments

This study was supported by the Health Research Fund of the 454th Hospital of Chinese PLA (12YY009).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xiao-yan Gu
    • 1
  • Jun Wang
    • 2
  • Yi-zhou Luo
    • 3
  • Qiang Du
    • 4
  • Ruo-ran Li
    • 5
  • Hui Shi
    • 6
  • Tian-pei Yu
    • 1
  1. 1.Department of RehabilitationThe 454th Hospital of Chinese PLANanjingChina
  2. 2.Department of RespiratorySuzhou Kowloon Hospital affiliated with Shanghai Jiao Tong University School of MedicineSuzhouChina
  3. 3.Department of OncologyThe 454th Hospital of Chinese PLANanjingChina
  4. 4.Department of Respiratory MedicineThe Second Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  5. 5.Department of Respiratory MedicineXuzhou Central HospitalXuzhouChina
  6. 6.Department of GastroenterologyJinling HospitalNanjingChina

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