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NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis

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Tumor Biology

Abstract

Previous studies on the associations of the NFKB1 -94 insertion/deletion polymorphism with cancer risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of the NFKB1 -94 insertion/deletion polymorphism on cancer risk. A search of the literature by PubMed was performed to identify studies based on the predetermined inclusion criteria. Twenty-three studies consisting of 6,494 cases and 9,884 controls were identified and analyzed. Overall, significant association was observed between the polymorphism and cancer risk under all genetic models. Subgroup analysis according to ethnicity and cancer type also detected significant association. The NFKB1 -94 insertion/deletion polymorphism was associated with cancer risk in Asian population (dominant model: OR = 1.52, 95 % CI = 1.17–1.98; recessive model: OR = 1.50, 95 % CI = 1.26–1.79; II vs. DD: OR = 1.90, 95 % CI = 1.37–2.65; ID vs. DD: OR = 1.32, 95 % CI = 1.05–1.66; I vs. D: OR = 1.37, 95 % CI = 1.17–1.60), but not in Caucasian population. In addition, significant associations in OC, HCC, and OSCC were observed, but significant associations were not found in BC and LC. The current meta-analysis suggested that NFKB1 -94 insertion/deletion polymorphism may influence cancer risk in Asian population.

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Authors and Affiliations

  1. Department of Clinical Laboratory, The First People’s Hospital of Yancheng, Yancheng, Jiangsu, 224001, China

    Linlin Xu

  2. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China

    Shaoyi Huang

  3. Department of Neurosurgery, The Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China

    Wei Chen

  4. Clinical Laboratory of the Sixth Affiliated Hospital of Wenzhou Medical University & Lishui People’s Hospital, Lishui, Zhejiang, China

    Zhichun Song

  5. Outpatient Department, Second Hospital of Yancheng, Yancheng, Jiangsu, China

    Shu Cai

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  1. Linlin Xu
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  2. Shaoyi Huang
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  3. Wei Chen
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  4. Zhichun Song
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Correspondence to Linlin Xu.

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Xu, L., Huang, S., Chen, W. et al. NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis. Tumor Biol. 35, 5181–5187 (2014). https://doi.org/10.1007/s13277-014-1672-z

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  • DOI: https://doi.org/10.1007/s13277-014-1672-z

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