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Tumor Biology

, Volume 35, Issue 5, pp 4983–4986 | Cite as

Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

  • Rubistenia Miranda Soares de Araújo
  • Cynthia Farias Vieira de Melo
  • Fidelis Manes Neto
  • Juarez Nóbrega da Silva
  • Leonardo Ferreira Soares
  • Marilia de Arruda Cardoso Smith
  • Edilson Carvalho SousaJr.
  • Rommel Mario Rodríguez Burbano
  • Arnaldo Correia de Medeiros
  • Eleonidas Moura Lima
Research Article

Abstract

Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher’s exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (χ 2 = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.

Keywords

SNPs Gastric cancer GSTP1 

Notes

Acknowledgements

This work was supported by grants of CAPES and CNPq. The authors would like to thank James overall for proofreading the article.

Conflict of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Rubistenia Miranda Soares de Araújo
    • 1
  • Cynthia Farias Vieira de Melo
    • 1
  • Fidelis Manes Neto
    • 4
  • Juarez Nóbrega da Silva
    • 1
  • Leonardo Ferreira Soares
    • 5
  • Marilia de Arruda Cardoso Smith
    • 6
  • Edilson Carvalho SousaJr.
    • 4
  • Rommel Mario Rodríguez Burbano
    • 7
  • Arnaldo Correia de Medeiros
    • 3
  • Eleonidas Moura Lima
    • 2
  1. 1.Graduate Program in Cellular and Molecular Biology and Laboratory of Structural Molecular Biology and Oncogenetics—LBMEO, Department of Molecular BiologyFederal University of Paraíba UFPBJoao PessoaBrazil
  2. 2.Laboratory of Structural Molecular Biology and Oncogenetics—LBMEO, Department of Molecular Biology, CCENFederal University of Paraíba UFPB, s/nJoão PessoaBrazil
  3. 3.Department of MedicineFederal University of Paraíba UFPBJoao PessoaBrazil
  4. 4.Department of GastroenterologyHospital São MarcosTeresinaBrazil
  5. 5.Department of PharmacyState University of Paraíba UEPBCampina GrandeBrazil
  6. 6.Department of Morphology and GeneticsFederal University of São PauloSao PauloBrazil
  7. 7.Department of Biology, Center of Biological SciencesFederal University of ParáBelemBrazil

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