Tumor Biology

, Volume 35, Issue 5, pp 4937–4941 | Cite as

Genetic association of CHEK2, GSTP1, and ERCC1 with glioblastoma in the Han Chinese population

  • Yu-Shu Dong
  • Wu-Gang Hou
  • Xiao-Lan Li
  • Tian-Bo Jin
  • Yue Li
  • Da-Yun Feng
  • De-Bao Liu
  • Guo-Dong Gao
  • Zhong-Min YinEmail author
  • Huai-Zhou QinEmail author
Research Article


Glioblastoma (GBM), a deadly brain tumor, is the most malignant glioma. It mainly occurs in adults and occurs significantly more in males than in females. We genotyped 19 tag single nucleotide polymorphisms (tSNPs) from 13 genes in a case–control study of the Han Chinese population to identify genetic factors contributing to the risk of GBM. These tSNPs were genotyped by Sequenom MassARRAY RS1000. Statistical analysis was performed using χ 2 test and SNPStats, a website software. Using χ 2 test, we found that the distribution of two tSNPs (rs2267130 in checkpoint kinase 2 (CHEK2), p = 0.040; rs1695 in GSTP1, p = 0.023) allelic frequencies had significant difference between cases and controls. When we analyzed all of the tSNPs using the SNPStats software, we found that rs1695 in GSTP1 decreased the risk of GBM in log-additive model (OR = 0.56, 95 % CI, 0.34–0.94, p = 0.022). Besides, we found that there is an interaction between rs3212986 in excision repair cross-complementing group 1 (ERCC1) and gender under codominant and recessive models. The gene polymorphisms in CHEK2, GSTP1, and ERCC1 may be involved in GBM in the Han Chinese population. Since our sample size is small, further investigation needs to be performed.


Glioblastoma (GBM) Tag single nucleotide polymorphism (tSNP) Case–control study CHEK2 GSTP1 ERCC1 



This work was supported by China Postdoctoral Science Foundation funded projects (no. 2012M521798). We would also like to thank BioScience Writers for their assistance in the preparation of this manuscript.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Yu-Shu Dong
    • 1
    • 2
  • Wu-Gang Hou
    • 3
  • Xiao-Lan Li
    • 4
  • Tian-Bo Jin
    • 4
  • Yue Li
    • 5
  • Da-Yun Feng
    • 1
  • De-Bao Liu
    • 5
  • Guo-Dong Gao
    • 1
  • Zhong-Min Yin
    • 2
    Email author
  • Huai-Zhou Qin
    • 1
    Email author
  1. 1.Department of Neurosurgery, Tangdu HospitalThe Fourth Military Medical UniversityXi’anChina
  2. 2.Department of Neurosurgery463rd Hospital of PLAShenyangChina
  3. 3.Department of Anesthesiology, Xijing HospitalThe Fourth Military Medical UniversityXi’anChina
  4. 4.National Engineering Research Center for Miniaturized Detection Systems, School of Life SciencesNorthwest UniversityXi’anChina
  5. 5.Department of Air Logistics463rd Hospital of PLAShenyangChina

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