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Tumor Biology

, Volume 35, Issue 5, pp 4697–4704 | Cite as

ERCC1 and BRCA1 mRNA expressions are associated with clinical outcome of non-small cell lung cancer treated with platinum-based chemotherapy

  • Xiuguang Qin
  • Wenjian Yao
  • Weiwei Li
  • Xianjun Feng
  • Xiaoqing Huo
  • Shujuan Yang
  • Hui Zhao
  • Xiaomeng Gu
Research Article

Abstract

We conducted a perspective study to investigate whether the expression of excision repair cross-complementing 1 (ERCC1), xeroderma pigmentosum group G (XPG), breast cancer 1 (BRCA1), and ribonucleotide reductase M1 (RRM1) is correlated with clinical outcome of non-small cell lung cancer (NSCLC). Patients with histologically confirmed inoperable stages IIIB and IV NSCLC were collected and followed up until January 2012. Relative cDNA quantification for ERCC1, XPG, BRCA1, and RRM1 was performed using a fluorescence-based, real-time detection method. Cox regression analysis indicated that a high level of ERCC1 was associated with shorter overall survival (OS) and progression-free survival (PFS) times when compared with low expression, with adjusted hazard ratios (HRs) (95 % confidence interval (CI)) of 2.25 (1.18–4.39) and 2.63 (1.33–5.25), respectively. High expression of BRCA1 was correlated with shorter OS and PFS times when compared with low expression, and the adjusted HRs (95 % CI) were 3.29 (1.72–6.39) and 5.94 (2.80–13.06), respectively. Moreover, we found a significant correlation between BRCA1 expression and age (χ 2 = 4.14, P = 0.04) and stage (χ 2 = 5.26, P = 0.02). Our results suggest that ERCC1 and BRCA1 mRNA expressions are associated with PFS and OS in advanced NSCLC patients treated with platinum-based chemotherapy.

Keywords

ERCC1 BRCA1 mRNA Non-small cell lung cancer Platinum-based chemotherapy Clinical outcome 

Notes

Acknowledgments

We thank the staffs of the First Affiliated Hospital of Xinxiang Medical University for their help and patients who agreed to provide blood samples.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xiuguang Qin
    • 1
  • Wenjian Yao
    • 1
  • Weiwei Li
    • 2
  • Xianjun Feng
    • 3
  • Xiaoqing Huo
    • 2
  • Shujuan Yang
    • 4
  • Hui Zhao
    • 5
  • Xiaomeng Gu
    • 6
  1. 1.Department of Thoracic SurgeryThe First Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  2. 2.Oncology DepartmentThe First Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  3. 3.Department of Respiratory MedicineThe First Affiliated Hospital of Xinxiang Medical UniversityWeihuiChina
  4. 4.Department of Health and Social Behavior, West China School of Public HealthSichuan UniversityChengduChina
  5. 5.Department of Thoracic Surgery, Qilu HospitalShandong UniversityJinanChina
  6. 6.Department of Gastroenterology, Qilu HospitalShandong UniversityJinanChina

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