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Tumor Biology

, Volume 35, Issue 5, pp 4659–4665 | Cite as

Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking

  • Xiaoyu Li
  • Jing Xu
  • Xinxin Yang
  • Yungang Wu
  • Baohua Cheng
  • Dongfeng Chen
  • Bo Bai
Research Article

Abstract

We investigated the potential association of 12 single nucleotide polymorphisms (SNPs) of nucleotide excision repair (NER) genes with risk of laryngeal cancer. A ratio of 1:1 matched case–control study was conducted. Conditional regression analysis indicated that subjects with ERCC1 rs11615 CC and C allele had an increased risk of laryngeal cancer compared with the TT genotype. Individuals with the ERCC5 rs17655 GG and G allele had a moderately increased risk of laryngeal cancer when compared with the CC genotype. By stratified analysis, ERCC1 rs11615 CC genotype and C allele were significantly associated with greatly increased risk of laryngeal cancer in ever smokers. ERCC1 rs11615 and ERCC5 rs17655 polymorphisms were associated with a moderately increased risk of this cancer in ever drinkers. In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers. Our finding could be helpful in identifying people at high risk for the disease for early intervention.

Keywords

Single nucleotide polymorphism Laryngeal cancer DNA repaired gene 

Notes

Acknowledgments

This work was supported by the Shandong Provincial Natural Science Foundation of China (ZR2010HL045, ZR2010HL057), the Jining City Science and Technology Development Plan Program of the Jining Science and Technology Bureau (2012jnfs02, 2012jnfs11, 2012jnfs13), the Youth Fund of Jining Medical University (JYQ2011KZ005), and the Shandong Province Higher Educational Science and Technology Program (J12LE10).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xiaoyu Li
    • 1
  • Jing Xu
    • 2
  • Xinxin Yang
    • 1
  • Yungang Wu
    • 1
  • Baohua Cheng
    • 3
  • Dongfeng Chen
    • 4
  • Bo Bai
    • 5
  1. 1.Department of Otolaryngology Head and Neck SurgeryThe Affiliated Hospital of Jining Medical UniversityJiningChina
  2. 2.The Affiliated Hospital of Jining Medical UniversityTianjinChina
  3. 3.Department of AnatomyJining Medical UniversityJiningChina
  4. 4.Department of UltrasoundThe Affiliated Hospital of Jining Medical UniversityJiningChina
  5. 5.Department of PhysiologyJining Medical UniversityJiningChina

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