Association of single nucleotide polymorphisms of nucleotide excision repair genes with laryngeal cancer risk and interaction with cigarette smoking and alcohol drinking
We investigated the potential association of 12 single nucleotide polymorphisms (SNPs) of nucleotide excision repair (NER) genes with risk of laryngeal cancer. A ratio of 1:1 matched case–control study was conducted. Conditional regression analysis indicated that subjects with ERCC1 rs11615 CC and C allele had an increased risk of laryngeal cancer compared with the TT genotype. Individuals with the ERCC5 rs17655 GG and G allele had a moderately increased risk of laryngeal cancer when compared with the CC genotype. By stratified analysis, ERCC1 rs11615 CC genotype and C allele were significantly associated with greatly increased risk of laryngeal cancer in ever smokers. ERCC1 rs11615 and ERCC5 rs17655 polymorphisms were associated with a moderately increased risk of this cancer in ever drinkers. In summary, we suggest that genetic variations in ERCC1 rs11615 and ERCC5 rs17655 are associated with laryngeal cancer risk in a Chinese population, especially in ever smokers and drinkers. Our finding could be helpful in identifying people at high risk for the disease for early intervention.
KeywordsSingle nucleotide polymorphism Laryngeal cancer DNA repaired gene
This work was supported by the Shandong Provincial Natural Science Foundation of China (ZR2010HL045, ZR2010HL057), the Jining City Science and Technology Development Plan Program of the Jining Science and Technology Bureau (2012jnfs02, 2012jnfs11, 2012jnfs13), the Youth Fund of Jining Medical University (JYQ2011KZ005), and the Shandong Province Higher Educational Science and Technology Program (J12LE10).
Conflicts of interest
- 1.GLOBOCAN 2008. International Agency for Research on Cancer (Online) Available at: http://globocan.iarc.fr/factsheets/populations/factsheet. Accessed on 28th May 2011.
- 13.Abbasi R, Ramroth H, Becher H, Dietz A, Schmezer P, Popanda O. Laryngeal cancer risk associated with smoking and alcohol consumption is modified by genetic polymorphisms in ERCC5, ERCC6 and RAD23B but not by polymorphisms in five other nucleotide excision repair genes. Int J Cancer. 2009;125:1431–9.CrossRefPubMedGoogle Scholar
- 15.Larynx. In: Edge SB, Byrd DR, Compton CC, et al., eds. AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010. pp. 57–62.Google Scholar
- 25.International Agency for Rescarch on Cancer, World Health Organization. Alcohol drinking. Lyon: World Health Organization, International Agency for Research on Cancer; 1988. p. 8.Google Scholar