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RETRACTED ARTICLE: Lack of association of XRCC1 rs1799782 genetic polymorphism with risk of pancreatic cancer: a meta-analysis

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Tumor Biology

This article was retracted on 20 April 2017

Abstract

Emerging evidence suggests that genetic polymorphisms in X-ray repair cross-complementation group 1 (XRCC1) gene could be associated with pancreatic cancer risk. However, previous published studies on the association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk reported inconsistent results. For better understanding of the effects of XRCC1 rs1799782 genetic polymorphism on pancreatic cancer risk, we conducted a meta-analysis of previous published studies by calculating the pooled odds ratio (OR) with a 95 % confidence interval (95 % CI). A total of five eligible studies with 1,144 pancreatic cancer cases and 2,925 controls were eventually enrolled. Overall, we found that the XRCC1 rs1799782 genetic polymorphism was not associated with pancreatic cancer risk in total population under all genetic models (TT vs. CC: OR = 1.11, 95 % CI 0.76–1.63, P = 0.583; CT vs. CC: OR = 1.39, 95 % CI 0.92–2.10, P = 0.118; TT/CT vs. CC: OR = 1.39, 95 % CI 0.92–2.10, P = 0.121; TT vs. CT/CC: OR = 1.07, 95 % CI 0.73–1.55, P = 0.743; T vs. C: OR = 1.31, 95 % CI 0.93–1.86, P = 0.125). In the subgroup analysis based on ethnicity, there was no statistically significant association between XRCC1 rs1799782 genetic polymorphism and pancreatic cancer risk in Asians/Caucasians under all genetic models (all P values > 0.05). No publication bias was detected in this study. Our meta-analysis suggests that the XRCC1 rs1799782 genetic polymorphism is not significantly associated with pancreatic cancer risk. Considering the limited sample size and ethnicity enrolled in this meta-analysis, further larger scaled studies are needed to provide a more precise estimation on the association.

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Acknowledgments

This work was supported by Science and Technology Plan Projects of Hunan Province (2012FJ3105).

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Authors and Affiliations

  1. Center of Transplant Surgery, The Third Xiangya Hospital, Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, 410013, Hunan, China

    Gengsheng He & Qifa Ye

  2. Department of General Surgery, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China

    Gengsheng He, Guodong Chen, Wei Zhang & Jinmin Cao

  3. Department of Oncology, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China

    Wenqi Chen

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  1. Gengsheng He
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  2. Guodong Chen
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  3. Wenqi Chen
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  4. Wei Zhang
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  5. Jinmin Cao
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  6. Qifa Ye
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Corresponding author

Correspondence to Qifa Ye.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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He, G., Chen, G., Chen, W. et al. RETRACTED ARTICLE: Lack of association of XRCC1 rs1799782 genetic polymorphism with risk of pancreatic cancer: a meta-analysis. Tumor Biol. 35, 4545–4550 (2014). https://doi.org/10.1007/s13277-013-1598-x

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  • DOI: https://doi.org/10.1007/s13277-013-1598-x

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