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The function of EMSY in cancer development

Tumor Biology volume 35, pages 5061–5066 (2014)Cite this article

Abstract

EMSY was first reported to bind BRCA2 and to inactivate the function of BRCA2, leading to the development of sporadic breast and ovarian cancers. The function of EMSY may also be involved in DNA damage repair, genomic instability, and chromatin remolding. Recent studies have shown that amplification of EMSY was also associated with other cancers such as prostate and pancreatic cancers and linked to tumor phenotypes and clinical outcomes. By reviewing literatures published since 2003, here, we have summarized the recent advances of EMSY in cancer development.

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Acknowledgements

This work was supported by the key project of Shanghai Municipal Health Bureau (#20114009) and the National Nature Science Foundation of China (#91129721) for Gong Yang and by the National Nature Science Foundation of China (#81072164) for Xiaomao Guo.

Conflict of interest

We have no conflict of interest and financial disclosure statements.

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Affiliations

  1. Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Jing Hou, Ziliang Wang, Lina Yang, Xiaomao Guo & Gong Yang

  2. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

    Jing Hou & Xiaomao Guo

  3. Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong’an Road, Shanghai, 200032, China

    Jing Hou, Ziliang Wang, Lina Yang, Xiaomao Guo & Gong Yang

Authors
  1. Jing Hou
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  2. Ziliang Wang
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  3. Lina Yang
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  4. Xiaomao Guo
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  5. Gong Yang
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Corresponding authors

Correspondence to Xiaomao Guo or Gong Yang.

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Cite this article

Hou, J., Wang, Z., Yang, L. et al. The function of EMSY in cancer development. Tumor Biol. 35, 5061–5066 (2014). https://doi.org/10.1007/s13277-013-1584-3

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  • DOI: https://doi.org/10.1007/s13277-013-1584-3

Keywords

  • EMSY
  • BRCA2
  • DNA repair
  • AKT
  • Genomic instability