Tumor Biology

, Volume 35, Issue 5, pp 4377–4380 | Cite as

Clinical significance of RKIP mRNA expression in non-small cell lung cancer

  • Qin Wang
  • Xiaodong Wu
  • Ting Wu
  • Gui-mei Li
  • Yi Shi
Research Article


Raf-1 kinase inhibitor protein (RKIP) expression was associated with the onset, development, invasion, and metastasis of numerous tumor types including prostate cancer, melanoma, colorectal cancer, liver cancer, and breast cancer. However, RKIP mRNA expression and the clinical significance in non-small cell lung cancers (NSCLC) remain unresolved. Real-time PCR was performed to detect the expression of RKIP mRNA in 126 pairs of lung tumor tissues (TT) and surrounding normal tissues (sNT). Correlations between RKIP mRNA expression and clinicopathological features were evaluated by statistical analysis. In the 126 patients examined, RKIP mRNA expression was significantly lower in lung TT than the sNT (p < 0.05). Our results indicated that downregulation of RKIP mRNA expression was associated with a poorer N-stage (p = 0.019) and poorer pathological TNM stage (p = 0.015). However, no significant association was observed between the expression status of RKIP mRNA and clinicopathologic factors, such as gender, age, histological type, and the size of the tumor (p > 0.05). The level of RKIP mRNA expression was found to be significantly downregulated in NSCLC, and the lower mRNA levels correlated with poorer differentiation, advanced pathologic TNM stage in patients with NSCLC.


Raf-1 kinase inhibitor protein Real-Time PCR Non-small cell lung cancers 



This work was supported by a grant form Nanjing General Hospital Foundation “Cancer associated fibroblasts promote angiogenesis and metastasis by secreting periostin in non-small cell lung cancer” (2013020).

Conflict of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Qin Wang
    • 1
  • Xiaodong Wu
    • 2
  • Ting Wu
    • 2
  • Gui-mei Li
    • 3
  • Yi Shi
    • 1
  1. 1.Department of Respiratory and Critical Care Medicine, Jinling Hospital, Clinical School of NanjingSecond Military Medical UniversityNanjingChina
  2. 2.Nanjing University School of MedicineNanjingChina
  3. 3.Department of PathologyNo. 81 Hospital of PLANanjingChina

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