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Tumor Biology

, Volume 35, Issue 5, pp 4107–4112 | Cite as

Associations between Fas/FasL polymorphisms and susceptibility to cervical cancer: a meta-analysis

  • Guo-qing Wang
  • Lei Bao
  • Xi-xia Zhao
  • Jun Zhang
  • Ke-jun Nan
Research Article

Abstract

Genetic polymorphisms in the Fas/Fas ligand (FasL) gene were proposed to be associated with susceptibility to cervical cancer, but previous studies reported controversial findings. We performed a meta-analysis to assess the associations between Fas/FasL polymorphisms and susceptibility to cervical cancer. We carried out a literature search in PubMed and Embase databases for studies on the associations between Fas/FasL polymorphisms and susceptibility to cervical cancer. The associations were assessed by odds ratio (OR) together with its 95 % confidence intervals (CIs). Eleven individual studies with a total of 6,919 subjects were finally included into the meta-analysis. Overall, there was no association between Fas 1377G > A polymorphism and susceptibility to cervical cancer (A vs. G: OR = 0.99, 95 % CI 0.88–1.12, P = 0.91; AA vs. GG: OR = 1.00, 95 % CI 0.76–1.32, P = 0.99; AA/GA vs. GG: OR = 0.95, 95 % CI 0.81–1.12, P = 0.54; AA vs. GG/GA: OR = 1.11, 95 % CI 0.85–1.43, P = 0.45). In addition, there was also no association between FasL 844 T > C polymorphism and susceptibility to cervical cancer (C vs. T: OR = 1.12, 95 % CI 0.91–1.36, P = 0.28; CC vs. TT: OR = 1.17, 95 % CI 0.90–1.51, P = 0.24; CC/TC vs. TT: OR = 1.13, 95 % CI 0.92–1.39, P = 0.24; CC vs. TT/TC: OR = 1.11, 95 % CI 0.83–1.50, P = 0.47). In subgroup analysis by ethnicity, there were also no associations between Fas/FasL polymorphisms and susceptibility to cervical cancer in Asians and Africans. In conclusion, Fas 1377G > A polymorphism and FasL 844 T > C polymorphism are both not associated with susceptibility to cervical cancer.

Keywords

Cervical cancer Fas FasL Meta-analysis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Guo-qing Wang
    • 1
    • 2
  • Lei Bao
    • 3
  • Xi-xia Zhao
    • 2
  • Jun Zhang
    • 2
  • Ke-jun Nan
    • 1
  1. 1.Department of OncologyFirst Affiliated Hospital of Xi-an Jiaotong University School of MedicineXi-anChina
  2. 2.Department of Gynecologic OncologyShanxi Cancer HospitalXi-anChina
  3. 3.Department of Obstetrics and GynecologyFourth Hospital of Xi-an CityXi-anChina

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