Tumor Biology

, Volume 35, Issue 5, pp 4041–4045 | Cite as

Association between X-ray repair cross-complementing group 1 Arg194Trp polymorphism and prostate cancer risk

  • Feng He
  • Guizhong Li
  • Libo Man
  • Ning Liu
Research Article


X-ray repair cross-complementing group 1 (XRCC1) plays an important role in the maintenance of the genomic integrity. Previous studies on the association between XRCC1 Arg194Trp polymorphism and prostate cancer risk reported conflicting results. To get a more precise assessment of the association between XRCC1 Arg194Trp polymorphism and prostate cancer risk, we performed a meta-analysis of previously published studies. Eligible studies were searched in PubMed, Embase, and China National Knowledge Infrastructure (CNKI) databases. Nine studies with a total of 5,407 subjects were finally included into the meta-analysis. Odds ratio (OR) with 95 % confidence interval (95 %CI) was used to assess the association. Overall, there was no obvious association between XRCC1 Arg194Trp polymorphism and prostate cancer risk (Trp vs. Arg: OR = 1.02, 95 %CI 0.84–1.25, P = 0.824; TrpTrp vs. ArgArg: OR = 1.17, 95 %CI 0.83–1.66, P = 0.374; TrpTrp/ArgTrp vs. ArgArg: OR = 1.00, 95 %CI 0.79–1.28, P = 0.990; TrpTrp vs. ArgArg/ArgTrp: OR = 1.20, 95 %CI 0.85–1.68, P = 0.301). Subgroup analysis according to ethnicity also detected no significant association in both Asians and Caucasians. In conclusion, the meta-analysis suggests that there is no obvious association between XRCC1 Arg194Trp polymorphism and prostate cancer risk.


XRCC1 Prostate cancer Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of Urinary SurgeryBeijing Jishuitan HospitalBeijingChina

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