Tumor Biology

, Volume 35, Issue 4, pp 3765–3770 | Cite as

Differential association of RANTES-403 and IL-1B-1464 polymorphisms on histological subtypes in male Korean patients with gastric cancer

  • Juwon Kim
  • Jong-Won Kim
  • Yoonjung Kim
  • Kyung-A LeeEmail author
Research Article


The aims of this study were to elucidate the association between RANTES-403 and an increased risk of gastric cancer in Korean males and to investigate the gene–gene interaction between IL-1B and RANTES. In total, 218 male patients with gastric cancer (114 diffuse types, 97 intestinal types, and 7 mixed types) and 377 male controls were included. RANTES-403 was genotyped, and age-adjusted odds ratios (ORs) with 95 % confidence intervals (CIs) were estimated by logistic regression. A multifactor dimensionality reduction (MDR) test with three-way split interval validation confirmed by likelihood ratio and permutation analysis was carried out. A significant increase in the risk of gastric cancer for the intestinal-type group was observed for IL-1B-1464G carriers (OR = 2.535; 95 % CI = 1.121–5.732; P = 0.02) as well as for those with IL-1B-1464 CG (OR = 2.342; 95 % CI = 0.998–5.500; P = 0.05) or IL-1B-1464 GG (OR = 2.819; 95 % CI = 1.170–6.793; P = 0.02). For the RANTES-403 genotype, there was no significant difference in the risk of gastric cancer between the overall gastric cancer and the control groups. When further stratified according to histological types, RANTES-403A carriers (OR = 1.743; 95 % CI = 1.086–2.798; P = 0.021) or heterozygotes (OR = 1.791; 95 % CI = 1.092–2.935; P = 0.021) showed increased risk for developing diffuse-type gastric cancer. MDR revealed a three-way locus–locus interaction between RANTES-403AA, IL-1B-1464GG, and IL-1B-511CT for diffuse-type gastric cancer in Korean males. We demonstrated that RANTES-403 was significantly associated with the risk of developing diffuse-type gastric cancer in men and found a possible gene–gene interaction between RANTES and IL-1B polymorphisms in gastric cancer carcinogenesis.


Gastric cancer IL-1B RANTES Diffuse type 



This work was supported by a research grant from Yonsei University School of Medicine in 2012.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Juwon Kim
    • 1
  • Jong-Won Kim
    • 2
  • Yoonjung Kim
    • 3
  • Kyung-A Lee
    • 3
    Email author
  1. 1.Department of Laboratory Wonju Severance Christian HospitalYonsei University Wonju College of MedicineWonjuKorea
  2. 2.Department of Laboratory Medicine and Genetics, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea
  3. 3.Department of Laboratory Medicine, Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea

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