STAG2 expression in oral cancer and potentially malignant lesions
Oral cancer is a world health problem, and one of the highest incidence rates of oral cancer worldwide occurs in Brazil. STAG2 is part of the cohesin complex which is responsible for sister chromatid cohesion. STAG2 loss of expression was reported in a range of tumors, and STAG2 loss was found to cause chromosomal instability and aneuploidy in cancer cells. On the basis of these findings, we investigated STAG2 expression in oral cancer and potentially malignant lesions. We investigated STAG2 immunoexpression in oral cancer, lip cancer, oral leukoplakia, and actinic cheilitis, including complete clinical information. Normal oral mucosa samples were included as normal controls. STAG2 protein was highly expressed in all samples. We further tested STAG2 expression in gastric adenocarcinomas and glioblastomas, as these tumor types were previously shown to lose STAG2 expression. We found homogenous expression of STAG2 by these tumor cells. Our results suggest that STAG2 loss of expression is not a common event in oral carcinogenesis.
KeywordsOral cancer Oral leukoplakia Actinic cheilitis Lip cancer STAG2 Glioblastoma Gastric adenocarcinoma
This study was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Gomes CC, Cardoso SV, Loyola AM, de Paula AMB, and Gomez RS are research fellows at the CNPq, Brazil. The authors would like to thank Miss Mirna Maciel D’Auriol Souza for her excellent technical assistance.
Conflicts of interest
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