Advertisement

Tumor Biology

, Volume 35, Issue 4, pp 3641–3645 | Cite as

STAG2 expression in oral cancer and potentially malignant lesions

  • Vanessa Fátima Bernardes
  • Gefter Thiago Batista Correa
  • Adriano Mota Loyola
  • Sérgio Vitorino Cardoso
  • Alfredo Maurício Batista de Paula
  • Mônica Maria Demas Álvares Cabral
  • Ricardo Santiago Gomez
  • Carolina Cavaliéri Gomes
Research Article

Abstract

Oral cancer is a world health problem, and one of the highest incidence rates of oral cancer worldwide occurs in Brazil. STAG2 is part of the cohesin complex which is responsible for sister chromatid cohesion. STAG2 loss of expression was reported in a range of tumors, and STAG2 loss was found to cause chromosomal instability and aneuploidy in cancer cells. On the basis of these findings, we investigated STAG2 expression in oral cancer and potentially malignant lesions. We investigated STAG2 immunoexpression in oral cancer, lip cancer, oral leukoplakia, and actinic cheilitis, including complete clinical information. Normal oral mucosa samples were included as normal controls. STAG2 protein was highly expressed in all samples. We further tested STAG2 expression in gastric adenocarcinomas and glioblastomas, as these tumor types were previously shown to lose STAG2 expression. We found homogenous expression of STAG2 by these tumor cells. Our results suggest that STAG2 loss of expression is not a common event in oral carcinogenesis.

Keywords

Oral cancer Oral leukoplakia Actinic cheilitis Lip cancer STAG2 Glioblastoma Gastric adenocarcinoma 

Notes

Acknowledgments

This study was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Gomes CC, Cardoso SV, Loyola AM, de Paula AMB, and Gomez RS are research fellows at the CNPq, Brazil. The authors would like to thank Miss Mirna Maciel D’Auriol Souza for her excellent technical assistance.

Conflicts of interest

None

References

  1. 1.
    de Camargo Cancela M, Voti L, Guerra-Yi M, Chapuis F, Mazuir M, Curado MP. Oral cavity cancer in developed and in developing countries: population-based incidence. Head Neck. 2010;32:357–67.PubMedGoogle Scholar
  2. 2.
    Estimate/2014: Cancer incidence in Brazil. In: Instituto Nacional de Câncer José Alencar Gomes da Silva http://www.inca.gov.br. Accessed 4 Nov 2013
  3. 3.
    Nasmyth K, Haering CH. Cohesin: its roles and mechanisms. Annu Rev Genet. 2009;43:525–58.PubMedCrossRefGoogle Scholar
  4. 4.
    Mannini L, Menga S, Musio A. The expanding universe of cohesin functions: a new genome stability caretaker involved in human disease and cancer. Hum Mutat. 2010;31:623–30.PubMedCrossRefGoogle Scholar
  5. 5.
    Solomon DA, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, Harris BT, et al. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011;333:1039–43.PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Kim MS, Kim SS, Je EM, Yoo NJ, Lee SH. Mutational and expressional analyses of STAG2 gene in solid cancers. Neoplasma. 2012;59:524–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Reshmi SC, Gollin SM. Chromosomal instability in oral cancer cells. J Dent Res. 2005;84:107–17.PubMedCrossRefGoogle Scholar
  8. 8.
    Bernstein JM, Bernstein CR, West CM, Homer JJ. Molecular and cellular processes underlying the hallmarks of head and neck cancer. Eur Arch Otorhinolaryngol. 2013;270:2585–93.PubMedCrossRefGoogle Scholar
  9. 9.
    American Joint Committee on Cancer. AJCC Cancer Staging Manual. New York: AJCC; 2002.Google Scholar
  10. 10.
    Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and genetics of head and neck tumours. Lyon: IARC; 2005.Google Scholar
  11. 11.
    Walker RA. Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment I. Histopathology. 2006;49:406–10.PubMedCrossRefGoogle Scholar
  12. 12.
    Almendro V, Marusyk A, Polyak K. Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol. 2013;8:277–302.PubMedCrossRefGoogle Scholar
  13. 13.
    Nassar A, Radhakrishnan A, Cabrero IA, Cotsonis GA, Cohen C. Intratumoral heterogeneity of immunohistochemical marker expression in breast carcinoma: a tissue microarray-based study. Appl Immunohistochem Mol Morphol. 2010;18:433–41.PubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Vanessa Fátima Bernardes
    • 1
  • Gefter Thiago Batista Correa
    • 2
  • Adriano Mota Loyola
    • 3
  • Sérgio Vitorino Cardoso
    • 3
  • Alfredo Maurício Batista de Paula
    • 4
  • Mônica Maria Demas Álvares Cabral
    • 5
  • Ricardo Santiago Gomez
    • 2
  • Carolina Cavaliéri Gomes
    • 1
  1. 1.Department of Pathology, Institute of Biological SciencesUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Oral Surgery and Pathology, School of DentistryUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Department of Oral Pathology, School of DentistryUniversidade Federal de UberlândiaUberlândiaBrazil
  4. 4.Department of DentistryUniversidade Estadual de Montes ClarosMontes ClarosBrazil
  5. 5.Department of Pathology and Forensic Medicine, School of MedicineUniversidade Federal de Minas GeraisBelo HorizonteBrazil

Personalised recommendations