Tumor Biology

, Volume 35, Issue 4, pp 3641–3645 | Cite as

STAG2 expression in oral cancer and potentially malignant lesions

  • Vanessa Fátima Bernardes
  • Gefter Thiago Batista Correa
  • Adriano Mota Loyola
  • Sérgio Vitorino Cardoso
  • Alfredo Maurício Batista de Paula
  • Mônica Maria Demas Álvares Cabral
  • Ricardo Santiago Gomez
  • Carolina Cavaliéri Gomes
Research Article


Oral cancer is a world health problem, and one of the highest incidence rates of oral cancer worldwide occurs in Brazil. STAG2 is part of the cohesin complex which is responsible for sister chromatid cohesion. STAG2 loss of expression was reported in a range of tumors, and STAG2 loss was found to cause chromosomal instability and aneuploidy in cancer cells. On the basis of these findings, we investigated STAG2 expression in oral cancer and potentially malignant lesions. We investigated STAG2 immunoexpression in oral cancer, lip cancer, oral leukoplakia, and actinic cheilitis, including complete clinical information. Normal oral mucosa samples were included as normal controls. STAG2 protein was highly expressed in all samples. We further tested STAG2 expression in gastric adenocarcinomas and glioblastomas, as these tumor types were previously shown to lose STAG2 expression. We found homogenous expression of STAG2 by these tumor cells. Our results suggest that STAG2 loss of expression is not a common event in oral carcinogenesis.


Oral cancer Oral leukoplakia Actinic cheilitis Lip cancer STAG2 Glioblastoma Gastric adenocarcinoma 



This study was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. Gomes CC, Cardoso SV, Loyola AM, de Paula AMB, and Gomez RS are research fellows at the CNPq, Brazil. The authors would like to thank Miss Mirna Maciel D’Auriol Souza for her excellent technical assistance.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Vanessa Fátima Bernardes
    • 1
  • Gefter Thiago Batista Correa
    • 2
  • Adriano Mota Loyola
    • 3
  • Sérgio Vitorino Cardoso
    • 3
  • Alfredo Maurício Batista de Paula
    • 4
  • Mônica Maria Demas Álvares Cabral
    • 5
  • Ricardo Santiago Gomez
    • 2
  • Carolina Cavaliéri Gomes
    • 1
  1. 1.Department of Pathology, Institute of Biological SciencesUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Oral Surgery and Pathology, School of DentistryUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Department of Oral Pathology, School of DentistryUniversidade Federal de UberlândiaUberlândiaBrazil
  4. 4.Department of DentistryUniversidade Estadual de Montes ClarosMontes ClarosBrazil
  5. 5.Department of Pathology and Forensic Medicine, School of MedicineUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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