Tumor Biology

, Volume 35, Issue 4, pp 3597–3603 | Cite as

The association of APE1 Asp148Glu gene polymorphisms and lung cancer risk: an updated meta-analysis

  • Wen Chen
  • Qin Wang
  • Mang Liu
  • Xiao-bing Ding
Research Article


Many studies have examined the association between APE1 Asp148Glu (rs3136820) polymorphism gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. PubMed and CNKI databases were searched for case–control studies published up to October 2013. Data were extracted, and pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated. Ultimately, 14 studies, comprising 4,165 lung cancer cases and 5,438 controls were included. Overall, for Glu carriers (Asp/Glu + Glu/Glu) versus wild-type homozygotes (Asp/Asp), the pooled OR was 1.05 (95 % CI = 0.96–1.15 P = 0.000 for heterogeneity); for Glu/Glu versus Asp/Asp, the pooled OR was 1.07 (95 % CI = 0.95–1.21 P = 0.007 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were not found among Asians or Caucasians. This updated meta-analysis suggests that the APE1 Asp148Glu polymorphisms are not associated with lung cancer risk among Asians or Caucasians.


APE1 Polymorphism Lung cancer Susceptibility Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Shanghai Xujiahui Community Medical Service CenterShanghaiChina
  2. 2.Department of Critical Care Medicine81 Hospital of PLANanjingChina
  3. 3.Jiangsu Province Hospital of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina

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