Tumor Biology

, Volume 35, Issue 4, pp 3597–3603 | Cite as

The association of APE1 Asp148Glu gene polymorphisms and lung cancer risk: an updated meta-analysis

Research Article

Abstract

Many studies have examined the association between APE1 Asp148Glu (rs3136820) polymorphism gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. PubMed and CNKI databases were searched for case–control studies published up to October 2013. Data were extracted, and pooled odds ratios (OR) with 95 % confidence intervals (CI) were calculated. Ultimately, 14 studies, comprising 4,165 lung cancer cases and 5,438 controls were included. Overall, for Glu carriers (Asp/Glu + Glu/Glu) versus wild-type homozygotes (Asp/Asp), the pooled OR was 1.05 (95 % CI = 0.96–1.15 P = 0.000 for heterogeneity); for Glu/Glu versus Asp/Asp, the pooled OR was 1.07 (95 % CI = 0.95–1.21 P = 0.007 for heterogeneity). In the stratified analysis by ethnicity, the significantly risks were not found among Asians or Caucasians. This updated meta-analysis suggests that the APE1 Asp148Glu polymorphisms are not associated with lung cancer risk among Asians or Caucasians.

Keywords

APE1 Polymorphism Lung cancer Susceptibility Meta-analysis 

Notes

Conflicts of interest

None

References

  1. 1.
    Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest. 2003;123:21–49.CrossRefGoogle Scholar
  2. 2.
    Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008;83:584–94.PubMedCentralPubMedGoogle Scholar
  3. 3.
    Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, et al. Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol. 2006;24:2245–51.PubMedCrossRefGoogle Scholar
  4. 4.
    Barzilay G, Hickson ID. Structure and function of apurinic/apyrimidinic endonucleases. Bioessays. 1995;17(8):713–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Tell G, Quadrifoglio F, Tiribelli C, Kelley MR. The many functions of APE1/Ref-1: not only a DNA repair enzyme. Antioxid Redox Signal. 2009;11(3):601–20.PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Izumi T, Hazra TK, Boldogh I, Tomkinson AE, Park MS, Ikeda S, et al. Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species. Carcinogenesis. 2000;21(7):1329–34.PubMedCrossRefGoogle Scholar
  7. 7.
    Bhakat KK, Mantha AK, Mitra S. Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. Antioxid Redox Signal. 2009;11(3):621–38.PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Tell G, Fantini D, Quadrifoglio F. Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment. Cell Mol Life Sci. 2010;67(21):3589–608.PubMedCrossRefGoogle Scholar
  9. 9.
    Xi T, Jones IM, Mohrenweiser HW. Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function. Genomics. 2004;83:970–9.PubMedCrossRefGoogle Scholar
  10. 10.
    Hu JJ, Smith TR, Miller MS, Mohrenweiser HW, Golden A, Case LD. Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. Carcinogenesis. 2001;22:917–22.PubMedCrossRefGoogle Scholar
  11. 11.
    Zhan P, Wang J, Lv XJ, Wang Q, Qiu LX, Lin XQ, et al. Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis. J Thorac Oncol. 2009;4(9):1094–103.PubMedCrossRefGoogle Scholar
  12. 12.
    Zhan P, Qian Q, Yu LK. Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. J Thorac Dis. 2013;5(1):40–7. doi: 10.3978/j.issn.2072-1439.2013.01.02.PubMedCentralPubMedGoogle Scholar
  13. 13.
    Zhan P, Qian Q, Wan B, Yan TD, Yu LK. Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: a meta-analysis. Transl Cancer Res. 2013. doi: 10.3978/j.issn.2218-676X.2013.02.08.Google Scholar
  14. 14.
    Zhan P, Wang Q, Qian Q, Yu LK. Megestrol acetate in cancer patients with anorexia-cachexia syndrome: a meta-analysis. Transl Cancer Res. 2013;2(2):74–9. doi: 10.3978/j.issn.2218-676X.2013.04.13.Google Scholar
  15. 15.
    Zhan P, Qian Q, Yu LK. Prognostic significance of vascular endothelial growth factor expression in hepatocellular carcinoma tissue: a meta-analysis. Hepatobiliary Surg Nutr. 2013. doi: 10.3978/j.issn.2304-3881.2013.06.06.Google Scholar
  16. 16.
    Zhan P, Qian Q, Yu LK. Serum VEGF level is associated with the outcome of patients with hepatocellular carcinoma: a meta-analysis. Hepatobiliary Surg Nutr. 2013. doi: 10.3978/j.issn.2304-3881.2013.06.07.Google Scholar
  17. 17.
    Zhan P, Ji YN, Yu LK. VEGF is associated with the poor survival of patients with prostate cancer: a meta-analysis. Transl Androl Urol. 2013. doi: 10.3978/j.issn.2223-4683.2013.07.01.Google Scholar
  18. 18.
    Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.CrossRefGoogle Scholar
  19. 19.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.PubMedGoogle Scholar
  20. 20.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.PubMedCrossRefGoogle Scholar
  21. 21.
    Tobias A. Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull. 1999;8:15–7.Google Scholar
  22. 22.
    Egger M, Davey Smith G, Schneider M, Minder C. Bias in metaanalysis detected by a simple, graphical test. BMJ. 1997;315:629–34.PubMedCentralPubMedCrossRefGoogle Scholar
  23. 23.
    Deng Q, Sheng L, Su D, Zhang L, Liu P, Lu K, et al. Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China. Med Oncol. 2011;28(3):667–72.PubMedCrossRefGoogle Scholar
  24. 24.
    Agaçhan B, Küçükhüseyin O, Aksoy P, Turna A, Yaylim I, Görmüs U, et al. Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking. Anticancer Res. 2009;29(6):2417–20.PubMedGoogle Scholar
  25. 25.
    Lo YL, Jou YS, Hsiao CF, Chang GC, Tsai YH, Su WC, et al. A polymorphism in the APE1 gene promoter is associated with lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18(1):223–9.PubMedCrossRefGoogle Scholar
  26. 26.
    De Ruyck K, Szaumkessel M, De Rudder I, Dehoorne A, Vral A, Claes K, et al. Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. Mutat Res. 2007;631(2):101–10.PubMedCrossRefGoogle Scholar
  27. 27.
    Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006;27(3):560–7.PubMedCrossRefGoogle Scholar
  28. 28.
    Matullo G, Dunning AM, Guarrera S, Baynes C, Polidoro S, Garte S, et al. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. Carcinogenesis. 2006;27(5):997–1007.PubMedCrossRefGoogle Scholar
  29. 29.
    Shen M, Berndt SI, Rothman N, Mumford JL, He X, Yeager M, et al. Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei. China Anticancer Res. 2005;25(1B):537–42.Google Scholar
  30. 30.
    Popanda O, Schattenberg T, Phong CT, Butkiewicz D, Risch A, Edler L, et al. Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. Carcinogenesis. 2004;25(12):2433–41.PubMedCrossRefGoogle Scholar
  31. 31.
    Ito H, Matsuo K, Hamajima N, Mitsudomi T, Sugiura T, Saito T, et al. Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk. Carcinogenesis. 2004;25(8):1395–401.PubMedCrossRefGoogle Scholar
  32. 32.
    Misra RR, Ratnasinghe D, Tangrea JA, Virtamo J, Andersen MR, Barrett M, et al. Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland. Cancer Lett. 2003;191(2):171–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Lu J, Zhang S, Chen D, Wang H, Wu W, Wang X, et al. Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility. FASEB J. 2009;23:3459–69.PubMedCrossRefGoogle Scholar
  34. 34.
    Osawa K, Miyaishi A, Uchino K, Osawa Y, Inoue N, Nakarai C, et al. APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese. Asian Pac J Cancer Prev. 2010;11:1181–6.PubMedGoogle Scholar
  35. 35.
    Li Z, Guan W, Li MX, Zhong ZY, Qian CY, Yang XQ, et al. Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population. Arch Med Res. 2011;42:226–34.PubMedCrossRefGoogle Scholar
  36. 36.
    Xue X, Yin Z, Lu Y, Zhang H, Yan Y, et al. The joint effect of hOGG1, APE1, and ADPRT polymorphisms and cooking oil fumes on the risk of lung adenocarcinoma in Chinese non-smoking females. PLoS ONE. 2013;8(8):e71157. doi: 10.1371/journal.pone.0071157.PubMedCentralPubMedCrossRefGoogle Scholar
  37. 37.
    Lindahl T. Recognition and processing of damaged DNA. J Cell Sci Suppl. 1995;19:73–7.PubMedCrossRefGoogle Scholar
  38. 38.
    Rodriguez C, Calle EE, Miracle-McMahill HL, Tatham LM, Wingo PA, Thun MJ, et al. Family history and risk of fatal prostate cancer. Epidemiology. 1997;8:653–9.PubMedCrossRefGoogle Scholar
  39. 39.
    Gu D, Wang M, Wang M, Zhang Z, Chen J. The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case–control studies. Mutagenesis. 2009;24(6):507–12.Google Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Shanghai Xujiahui Community Medical Service CenterShanghaiChina
  2. 2.Department of Critical Care Medicine81 Hospital of PLANanjingChina
  3. 3.Jiangsu Province Hospital of Traditional Chinese MedicineNanjing University of Traditional Chinese MedicineNanjingChina

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