Tumor Biology

, Volume 35, Issue 4, pp 3509–3515 | Cite as

The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population

  • Xu Wang
  • Jun Yin
  • Liang Zheng
  • Liming Wang
  • Yijun Shi
  • Weifeng Tang
  • Guowen Ding
  • Chao Liu
  • Ruiping Liu
  • Suocheng ChenEmail author
  • Haiyong GuEmail author
Research Article


To investigate the association between gastric cardiac adenocarcinoma (GCA) and six functional single nucleotide polymorphisms (SNPs) including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 G>A, IL3 rs40401 C>T, IL3 rs2073506 G>A, and IL7Rα rs6897932 A>G. We performed a hospital-based case–control study to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscanTM kit was used to determine the genotypes. The IL1f7 rs3811047 G>A polymorphism was significantly associated with a decreased risk of GCA either in the single locus analyses or the recessive genetic model. However, there was no significant association between the other five SNPs and GCA risk. These results elucidated that the functional polymorphism, IL1f7 rs3811047 G>A, might contribute to GCA susceptibility. However, the statistical power of our study was limited, large well-designed studies and further functional investigations are needed to confirm our findings.


IL1f7 Polymorphisms Gastric cardiac adenocarcinoma Molecular epidemiology 



Confidential interval


Gastric cardiac adenocarcinoma


Interleukin 7 receptor alpha


Odds ratio


Single nucleotide polymorphisms



We wish to thank Dr. Da Ding and Dr. Yan Liu (Genesky Biotechnologies Inc., Shanghai, China) for technical support.

Grant support

This study was supported in part by National Natural Science Foundation of China (81370001, 81371927, 81101889, 81000028), Jiangsu Province Natural Science Foundation (BK2010333, BK2011481), Social Development Foundation of Zhenjiang (SH2010017), Changzhou Young Talents and Science-Technology Foundation of Health Bureau (QN201102), Affiliated People’s Hospital of Jiangsu University fund (Y200913) and Jiangsu University Clinical medicine science and technology development fund (JLY20120004).

Condensed abstract

We performed a hospital-based case–control study to evaluate the genetic effects of six SNPs including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 G>A, IL3 rs40401 C>T, IL3 rs2073506 G>A, and IL7Rα rs6897932 A>G on the development of GCA. Our results demonstrated that functional variant IL1f7 rs3811047 G>A might contribute to GCA susceptibility.

Conflicts of interest

We declare that we have no conflicts of interest.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Xu Wang
    • 1
  • Jun Yin
    • 1
  • Liang Zheng
    • 2
  • Liming Wang
    • 3
  • Yijun Shi
    • 1
  • Weifeng Tang
    • 1
  • Guowen Ding
    • 1
  • Chao Liu
    • 1
  • Ruiping Liu
    • 4
  • Suocheng Chen
    • 1
    Email author
  • Haiyong Gu
    • 1
    • 5
    Email author
  1. 1.Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu UniversityZhenjiangChina
  2. 2.Department of Cardiothoracic SurgeryThe First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou UniversityChangzhouChina
  3. 3.Cancer institute, Department of chemotherapyPeople’s Hospital Affiliated to Jiangsu UniversityZhenjiangChina
  4. 4.Department of OrthopedicsAffiliated Hospital of Nanjing Medical University, Changzhou Second People’s HospitalChangzhouChina
  5. 5.Department of Cardiothoracic SurgeryAffiliated People’s Hospital of Jiangsu UniversityZhenjiangChina

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