NOV, a member of the CCN (Cyr61, CTGF and NOV) family, is involved in diverse biological processes, such as cell adhesion, proliferation and angiogenesis. However, its function in pancreatic cancer remains poorly understood. Here, we found that the expression of NOV was up-regulated in pancreatic cancer tissues. Moreover, over-expression of NOV in pancreatic cancer cells promoted cell proliferation and migration, while knock down the expression of NOV impaired the tumorigenecity of pancreatic cancer cells in vitro and in vivo. Mechanistically, NOV induced epithelial–mesenchymal transition (EMT) and regulated the expression of multiple EMT marker. Taken together, our study suggested the important role of NOV in pancreatic cancer and NOV might be an important therapeutic target.
NOV Pancreatic cancer Cancer metastasis EMT
This is a preview of subscription content, log in to check access.
Carver EA, Jiang R, Lan Y, Oram KF, Gridley T. The mouse snail gene encodes a key regulator of the epithelial–mesenchymal transition. Mol Cell Biol. 2001;21(23):8184–8.PubMedCentralPubMedCrossRefGoogle Scholar
Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008;22(7):894–907.PubMedCentralPubMedCrossRefGoogle Scholar
Kleer CG, Zhang Y, Pan Q, Merajver SD. WISP3 (CCN6) is a secreted tumorsuppressor protein that modulates IGF signaling in inflammatory breast cancer. Neoplasia. 2004;6:179–85.PubMedCentralPubMedCrossRefGoogle Scholar
Yu C, Le AT, Yeger H, Perbal B, Alman BA. NOV(CCN3) regulation in the growth plate and CCN family member expression in cartilage neoplasia. J Pathol. 2003;201:609–15.PubMedCrossRefGoogle Scholar
Albrecht N, Kristopher KF, Tashinga EB, et al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. PNAS. 2013;110:12325–30.CrossRefGoogle Scholar
Inamul H, Archana D, Monami M, et al. The matricellular protein CCN1/Cyr61 is a critical regulator of sonic hedgehog in pancreatic carcinogenesis. J Biol Chem. 2012;287:38569–79.CrossRefGoogle Scholar
Fidler IJ. The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer. 2003;3(6):453–8.PubMedCrossRefGoogle Scholar