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Tumor Biology

, Volume 35, Issue 4, pp 3195–3201 | Cite as

NOV promoted the growth and migration of pancreatic cancer cells

  • Lei Cui
  • Rong Xie
  • Shenchun Dang
  • Qing Zhang
  • Shengfa Mao
  • Jixiang Chen
  • Jianguo Qu
  • Jianxin Zhang
Research Article

Abstract

NOV, a member of the CCN (Cyr61, CTGF and NOV) family, is involved in diverse biological processes, such as cell adhesion, proliferation and angiogenesis. However, its function in pancreatic cancer remains poorly understood. Here, we found that the expression of NOV was up-regulated in pancreatic cancer tissues. Moreover, over-expression of NOV in pancreatic cancer cells promoted cell proliferation and migration, while knock down the expression of NOV impaired the tumorigenecity of pancreatic cancer cells in vitro and in vivo. Mechanistically, NOV induced epithelial–mesenchymal transition (EMT) and regulated the expression of multiple EMT marker. Taken together, our study suggested the important role of NOV in pancreatic cancer and NOV might be an important therapeutic target.

Keywords

NOV Pancreatic cancer Cancer metastasis EMT 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Lei Cui
    • 1
  • Rong Xie
    • 1
  • Shenchun Dang
    • 1
  • Qing Zhang
    • 1
  • Shengfa Mao
    • 1
  • Jixiang Chen
    • 1
  • Jianguo Qu
    • 1
  • Jianxin Zhang
    • 1
    • 2
  1. 1.General Surgery Department, Affiliated hospitalJiangsu UniversityZhenjiangChina
  2. 2.Affiliated HospitalJiangsu UniversityZhenjiangChina

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