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MDM2 rs2279744 polymorphism and endometrial cancer: a meta-analysis

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Tumor Biology

Abstract

Case–control studies on the association between mouse double minute 2 homolog (MDM2) rs2279744 polymorphism and endometrial cancer have provided either controversial or inconclusive results. To clarify the effect of MDM2 rs2279744 polymorphism on the risk of endometrial cancer, a meta-analysis of all case–control observational studies was performed. Pooled odds ratios (ORs) for various polymorphisms were estimated using random and fixed effect models. Q-statistic was used to evaluate the homogeneity, and Egger and Begg tests were used to assess publication bias. Overall, the MDM2 rs2279744 polymorphism was associated with a risk of endometrial cancer (OR = 0.76; 95 % CI = 0.64–0.90 for allele contrast, p = 0.002, P het = 0.003). The contrast of homozygotes and the recessive and dominant models produced the same pattern of results as the allele contrast. In the analysis stratified by ethnicity, significant associations were found in the Caucasian population in all of the genetic models. Our pooled data suggest evidence for a major role of MDM2 rs2279744 polymorphism in the carcinogenesis of endometrial cancer, especially among Caucasian populations.

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Acknowledgments

This work was supported by the Science and Technology Project of Traditional Chinese Medicines of Jiangsu Province in 2011–2012 (LZ11153) and the Innovation Research Project for postgraduates in Colleges of Jiangsu Province in 2011 (funding) (CXZZ11_0780).

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Authors and Affiliations

  1. The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, 210046, People’s Republic of China

    Li-Hong Wang, Xu Wang & Ya-Li Hu

  2. Zhangjiagang Hospital of Chinese Medicine, Zhangjiagang, 215600, People’s Republic of China

    Li-Hong Wang & Wen-Ting Xu

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  1. Li-Hong Wang
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  2. Xu Wang
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  3. Wen-Ting Xu
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  4. Ya-Li Hu
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Correspondence to Xu Wang.

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Wang, LH., Wang, X., Xu, WT. et al. MDM2 rs2279744 polymorphism and endometrial cancer: a meta-analysis. Tumor Biol. 35, 3167–3170 (2014). https://doi.org/10.1007/s13277-013-1413-8

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  • DOI: https://doi.org/10.1007/s13277-013-1413-8

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