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Tumor Biology

, Volume 35, Issue 4, pp 3113–3117 | Cite as

Two-gene expression ratio as predictor for breast cancer treated with tamoxifen: evidence from meta-analysis

  • Lin Zhao
  • Shimiao Zhu
  • Ying Gao
  • Yaogang Wang
Research Article

Abstract

A HOXB13-to-IL17BR expression ratio was previously identified to predict a clinical outcome of breast cancer patients treated with adjuvant tamoxifen. A large number of studies were addressed to confirm its function as a predictor of breast cancer outcome treated with tamoxifen. However, conflicting results were got. In this study, a systematic search of databases was carried out, and other relevant papers were also identified. Then, the analyses were conducted according to the PRISMA and MOOSE guidelines. After full review, 11 studies with a total of 2,958 participants were deemed eligible and were included in the study. Pooled results revealed that women with higher HOXB13-to-IL17BR expression ratio had significantly worse outcomes in breast patients treated with tamoxifen, especially for those who are negative of node.

Keywords

HOXB13 IL17BR Meta-analysis Breast cancer Tamoxifen 

Notes

Acknowledgments

The work was supported by the Key Project of Science and Technology, Tianjin Municipal Science and Technology Commission (grant no. 11ZCGYSY02200). The authors thank all of the authors of primary studies included in their meta-analyses.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.International Medical SchoolTianjin Medical UniversityTianjinChina
  2. 2.Department of Urology, The Tianjin Institute of UrologyThe Second Hospital of Tianjin Medical UniversityTianjinChina
  3. 3.School of Public HealthTianjin Medical UniversityTianjinChina

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