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Tumor Biology

, Volume 35, Issue 4, pp 3067–3071 | Cite as

Prognostic role of microRNA-100 in various carcinomas: evidence from six studies

  • Jie Chen
  • Biqiang Zheng
  • Chunmeng Wang
  • Yong Chen
  • Chunyan Du
  • Guangfa Zhao
  • Ye Zhou
  • Yingqiang Shi
Research Article

Abstract

Recent studies have shown that microRNAs (miRNA) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for patients with cancers. We performed this meta-analysis to provide a comprehensive evaluation of the role of miRNA-100 expression on the overall survival rate by calculating the pooled hazard ratio (HR) for overall survival (OS), which compared the high and low expression levels of miR-100 in patients of the available studies. Finally, a total of six studies dealing with various carcinomas were involved for this meta-analysis. The results indicated that lower expression of miR-100 in cancerous tissue could significantly predict poorer survival in various carcinomas with the pooled HR of 2.19 (95 % CI 1.49–3.24, P = 0.0007). In conclusion, the findings from this present meta-analysis suggest that miR-100 expression is associated with OS in cancer patients and could be a useful clinical prognostic factor for those patients.

Keywords

MicroRNA-100 Cancer Prognosis Meta-analysis 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Jie Chen
    • 1
    • 2
  • Biqiang Zheng
    • 1
    • 2
  • Chunmeng Wang
    • 1
    • 2
  • Yong Chen
    • 1
    • 2
  • Chunyan Du
    • 1
    • 2
  • Guangfa Zhao
    • 1
    • 2
  • Ye Zhou
    • 1
    • 2
  • Yingqiang Shi
    • 1
    • 2
  1. 1.Department of Gastric Cancer and Soft Tissue SarcomasFudan University Shanghai Cancer CenterShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina

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