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Tumor Biology

, Volume 35, Issue 4, pp 2831–2836 | Cite as

Aurora-A: a potential DNA repair modulator

  • Yan Wang
  • Huizhen Sun
  • Ziliang Wang
  • Mingming Liu
  • Zihao Qi
  • Jiao Meng
  • Jianmin Sun
  • Gong Yang
Review

Abstract

It is well-known that overexpression of Aurora-A promotes tumorigenesis, but the role of Aurora-A in the development of cancer has not been fully investigated. Recent studies indicate that Aurora-A may confer cancer cell chemo- and radioresistance through dysregulation of cell cycle progression and DNA damage response. Direct evidences from literatures suggest that Aurora-A inhibits pRb, p53, p21waf1/cip1, and p27cip/kip but enhances Plk1, CDC25, CDK1, and cyclin B1 to repeal cell cycle checkpoints and to promote cell cycle progression. Other studies indicate that Aurora-A suppresses BRCA1, BRCA2, RAD51, poly(ADP ribose) polymerase (PARP), and gamma-H2AX to dysregulate DNA damage response. Aurora-A may also interact with RAS and Myc to control DNA repair indirectly. In this review, we summarized the potential role of Aurora-A in DNA repair from the current literatures and concluded that Aurora-A may function as a DNA repair modulator to control cancer cell radio- and chemosensitivity, and that Aurora-A-associated DNA repair molecules may be considered for targeted cancer therapy.

Keywords

Aurora-A p53 BRCA1/2 DNA damage repair Radio- and Chemoresistance 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Yan Wang
    • 1
    • 2
  • Huizhen Sun
    • 1
    • 2
  • Ziliang Wang
    • 1
    • 2
  • Mingming Liu
    • 1
    • 2
  • Zihao Qi
    • 1
    • 2
  • Jiao Meng
    • 1
    • 2
  • Jianmin Sun
    • 1
    • 2
  • Gong Yang
    • 1
    • 2
  1. 1.Cancer InstituteFudan University Shanghai Cancer CenterShanghaiChina
  2. 2.Department of Oncology, Shanghai MedicalFudan UniversityShanghaiChina

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