Advertisement

Tumor Biology

, Volume 35, Issue 4, pp 3941–3942 | Cite as

Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

  • Nicolas Jonckheere
  • Isabelle Van Seuningen
Research Commentary

Abstract

Gao and collaborators (Tumour Biol, 2013) have investigated the role of mucin 4 (MUC4) in lung cancer and have concluded that a loss of MUC4 results in epithelial mesenchymal transition via beta-catenin nuclear translocation and that MUC4 expression is correlated with a risk of lymph node metastasis in a cohort of 20 lung adenocarcinoma patients. This surprising analysis is contradictory to most of the scientific knowledge and literature regarding MUC4 contribution in epithelial cancers that is very hardly discussed in their manuscript.

Keywords

MUC4 Oncomucin Lung adenocarcinoma Epithelial mesenchymal transition 

Notes

Conflicts of interest

None

References

  1. 1.
    Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Tumour Biol. 2013 (in press).Google Scholar
  2. 2.
    Moniaux N, Nollet S, Porchet N, Degand P, Laine A, Aubert JP. Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J. 1999;338(Pt 2):325–33.PubMedCentralPubMedCrossRefGoogle Scholar
  3. 3.
    Porchet N, Nguyen VC, Dufosse J, Audie JP, Guyonnet-Duperat V, Gross MS, et al. Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem Biophys Res Commun. 1991;175(2):414–22.PubMedCrossRefGoogle Scholar
  4. 4.
    Bruyère E, Jonckheere N, Frenois F, Mariette C, Van Seuningen I. The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: implication for S100A4 protein. Biochem Biophys Res Commun. 2011;413(2):325–9.PubMedCrossRefGoogle Scholar
  5. 5.
    Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Leteurtre E, et al. The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. PLoS One. 2012;7(2):e32232.PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Kaur S, Kumar S, Momi N, Sasson AR, Batra SK. Mucins in pancreatic cancer and its microenvironment. Nat Rev Gastroenterol Hepatol. 2013;10:607–20.PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Bafna S, Kaur S, Momi N, Batra SK. Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin. Br J Cancer. 2009;101(7):1155–61.PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 2004;4(1):45–60.PubMedCrossRefGoogle Scholar
  9. 9.
    Skrypek N, Duchene B, Hebbar M, Leteurtre E, van Seuningen I, Jonckheere N. The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Oncogene. 2013;32(13):1714–23.PubMedCentralPubMedCrossRefGoogle Scholar
  10. 10.
    Tsutsumida H, Goto M, Kitajima S, Kubota I, Hirotsu Y, Wakimoto J, et al. MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma. Lung Cancer. 2007;55(2):195–203.PubMedCrossRefGoogle Scholar
  11. 11.
    Karg A, Dinc ZA, Basok O, Ucvet A. MUC4 expression and its relation to ErbB2 expression, apoptosis, proliferation, differentiation, and tumor stage in non-small cell lung cancer (NSCLC). Pathol Res Pract. 2006;202(8):577–83.PubMedCrossRefGoogle Scholar
  12. 12.
    Ponnusamy MP, Lakshmanan I, Jain M, Das S, Chakraborty S, Dey P, et al. MUC4 mucin-induced epithelial to mesenchymal transition: a novel mechanism for metastasis of human ovarian cancer cells. Oncogene. 2010;29(42):5741–54.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Nicolas Jonckheere
    • 1
    • 2
    • 3
  • Isabelle Van Seuningen
    • 1
    • 2
    • 3
  1. 1.UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”InsermLille CedexFrance
  2. 2.Université Lille Nord de FranceLille CedexFrance
  3. 3.Centre Hospitalier Régional et Universitaire de LilleLille CedexFrance

Personalised recommendations