Tumor Biology

, Volume 35, Issue 4, pp 3941–3942 | Cite as

Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

  • Nicolas Jonckheere
  • Isabelle Van Seuningen
Research Commentary


Gao and collaborators (Tumour Biol, 2013) have investigated the role of mucin 4 (MUC4) in lung cancer and have concluded that a loss of MUC4 results in epithelial mesenchymal transition via beta-catenin nuclear translocation and that MUC4 expression is correlated with a risk of lymph node metastasis in a cohort of 20 lung adenocarcinoma patients. This surprising analysis is contradictory to most of the scientific knowledge and literature regarding MUC4 contribution in epithelial cancers that is very hardly discussed in their manuscript.


MUC4 Oncomucin Lung adenocarcinoma Epithelial mesenchymal transition 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Nicolas Jonckheere
    • 1
    • 2
    • 3
  • Isabelle Van Seuningen
    • 1
    • 2
    • 3
  1. 1.UMR837, Jean Pierre Aubert Research Center, Team #5 “Mucins, epithelial differentiation and carcinogenesis”InsermLille CedexFrance
  2. 2.Université Lille Nord de FranceLille CedexFrance
  3. 3.Centre Hospitalier Régional et Universitaire de LilleLille CedexFrance

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